Gymnema sylvestre: An Alternative Therapeutic Agent for Management of Diabetes.

Gymnema sylvestre (Asclepiadaceae) also known as ‘gurmar’ or ‘sugar destroyer’ is a woody, climbing traditional medicinal herb which has many therapeutic applications in Ayurvedic system of medicine. It is used for lowering serum cholesterol, triglycerides and blood glucose level (hypoglycemic or antihyperglycemic), hypolipidaemic, weight loss, stomach ailments, constipation, water retention and liver diseases, either high or low blood pressure, tachycardia or arrhythmias, and used as aperitive, purgative, in eye troubles, antiinflammatory, smooth muscle relaxant, prevention of dental caries, cataract and as anticancer-cytotoxic agent. Its flowers, leaves, and fruits contains alkaloids, flavones, saponins, sapogenins, anthraquinones, hentri-acontane, pentatriacontane, α and β-chlorophylls, phytin, resins, d-quercitol, tartaric acid, formic acid, butyric acid, lupeol, β-amyrin related glycosides and stigmasterol having main principle bioactive compunds viz. gymnemic acids, gymnemasides, gymnemagenin, gurmarin, gymnemosides, gymnemanol, gymnemasins, gypenoside, and conduritol which act as therapeutic agent and play vital role in many therapeutic applications. Gymnemic acids are thought to be responsible for its antidiabetic activity and it is the major component of an extract shown to stimulate insulin release from the pancreas. Another anti-sweet agent gumarin is utilized as a pharmacological tool in the study of sweet-taste transduction. The commercial exploitation of this plant and their secondary metabolites are some of the major prospective of this rare medicinal herb. The focus of the present review is to achieve the potential of therapeutic value of this herb and mechanism and action of their secondary metabolites.

Internet resources for diabetes.

Internet is transforming lives of many people in the world. Nowadays Internet has become one of the most common media to extract information of interest to researchers. The Internet is composed of a large number of smaller interconnected networks called Intranets. These Intranets connect thousands computers enabling them to share information with each other and to share various resources such as powerful super computers, software and databases of information. It has made it possible for people all over the world to effectively and inexpensively communicate with each other. The Internet has become world's biggest library where retrieval of scientific resources is only a mouse click away. The geometric growth in Internet usage is mainly due to the great success of "World Wide Web". Various useful databases on diabetes are already on 'the Net' and many more being added regularly. The present article is an attempt to provide a review of several sites that may be of great significance to the diabetes researchers before execution for new assignment/project.