RESUMO
To determine the hypolipidemic effect of fenugreek [Methi] seeds and its comparison with atorvastatin on experimentally induced hyperlipidemia in rabbits. Experimental interventional study. Department of Physiology, Dr. S. N. Medical College, Jodhpur, Rajasthan, India, from April 2012 to March 2013. Twenty, 1 - 2 years old albino rabbits of European Strains were randomly divided into two groups of 10 rabbits each. All were fed pure cholesterol [0.5 g/kg body weight/day] for 4 weeks to induce hyperlipidemia. Group-I comprised of 10 hyperlipidemic rabbits which were fed normal [regular] diet supplemented with 2 ml aqueous emulsified fenugreek seeds powder [500 mg/kg body weight/day] for 4 weeks. Group-II comprised of 10 hyperlipidemic rabbits, which were fed normal [regular] diet supplemented with 2 ml aqueous emulsion of atorvastatin [0.5 mg/kg body weight/day] for 4 weeks. Fasting blood samples were collected two times during experimental period at weeks [4 and 8] and analyzed for serum total cholesterol and triglycerides, using semi-automated chemistry analyzer. HDL-C was determined by precipitation method and LDL-C and VLDL-C were estimated by Friedewalds formula. LDL/HDL ratio and TG/HDL ratios were also calculated. The significance of difference in mean values of both groups [lipid profile] was assessed by independent student's t-test. Atorvastatin showed a more potent hypolipidemic activity. It reduced serum total cholesterol, TG, LDL and VLDLcholesterol, and the atherogenic index [LDL-C/HDL-C; p < 0.001] highly significantly as compared to fenugreek. There was a significant increase of HDL-C [p < 0.01] in group-I as compared to group-II. Fenugreek and atorvastatin both have hypolipidemic activity in rabbits but atorvastatin is more potent than fenugreek seeds powder
RESUMO
Crouzon's syndrome is a rare autosomal dominant skeletal disorder caused by multiple mutations in the fibroblast growth factor receptor 2 [FGFR2] gene. Two genes are known to be associated with Crouzon syndrome, FGFR2 and FGFR3. FGFR stands for fibroblast growth factor receptor. These genes are involved in the growth of the skull bones. The FGFR2 gene is the most common gene associated with Crouzon syndrome. [1] Since human skull is made up of many bones, joined by sutures. The fusion of sutures takes place after the complete growth of the brain. If any of these sutures closes early, it may interfere with the normal growth of the brain and results in various syndromes, even though most people with Crouzon syndrome [97%] do not have mental retardation or learning problems. Only in 3% cases fusion of sutures in early life before the development of brain exerts pressure on the skull as well as on the developing brain itself and May results in an abnormal development and functioning of growing brain. We found such a rare case of Crouzons syndrome having the symptoms of headache, convulsions [complex partial seizures] associated with mental retardation which is not commonly seen in this syndrome
RESUMO
Ascaris lumbricoides [AL] is a common resident of intestine especially in low socioeconomic areas of the world. Ascariasis can cause serious intra-abdominal complications such as intestinal obstruction, biliary obstruction, pancreatitis, acute appendicitis, intestinal perforation etc. We report an adult with intestinal obstruction due to entangled mass of AL, that presented as a lump in right iliac fossa, managed by laparotomy and milking the worms into colon without enterotomy