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Background/Aims@#Liver cirrhosis is an important cause of morbidity and mortality globally. Every episode of decompensation and hospitalization reduces survival. We studied the clinical profile and long-term outcomes comparing alcohol-related cirrhosis (ALC) and non-ALC. @*Methods@#Cirrhosis patients at index hospitalisation (from January 2010 to June 2017), with ≥1 year follow-up were included. @*Results@#Five thousand and one hundred thirty-eight cirrhosis patients (age, 49.8±14.6 years; male, 79.5%; alcohol, 39.5%; Child-A:B:C, 11.7%:41.6%:46.8%) from their index hospitalization were analysed. The median time from diagnosis of cirrhosis to index hospitalization was 2 years (0.2–10). One thousand and seven hundred seven patients (33.2%) died within a year; 1,248 (24.3%) during index hospitalization. 59.5% (2,316/3,890) of the survivors, required at least one readmission, with additional mortality of 19.8% (459/2,316). ALC compared to non-ALC were more often (P @*Conclusions@#One-third of cirrhosis patients die in index hospitalization. 60% of the survivors require at least one rehospitalization within a year. ALC patients present with higher morbidity and mortality and at a younger age.
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The mechanical properties of polymers can be improved by electron beam irradiation. The aim of this study is to evaluate the mechanical properties of denture base resins after irradiation with electron beam with an energy dose of up to 25 KGy.METHODSIn this study, four different denture base resins were used namely, DPI, Trevalon, Trevalon HI, and Meliodent heat cure acrylic resins. Mechanical properties of the denture base resins after exposure to electron beam post-curing were studied. The irradiated denture base resins are compared with untreated control groups.RESULTSOur study showed that PMMA-based denture resins improved the mechanical properties after irradiation with electron beam. As the radiation dose increases to 25 KGy, the polymeric structure starts to break down, and C–C bonds are split off during electron beam irradiation.CONCLUSIONSMechanical properties such as flexural strength, impact strength, and hardness of DPI heat cure acrylic resin, Trevalon, Trevalon HI, and Meliodent heat cure acrylic resins can be modified by the lower dosage of electron beam irradiation. Denture base resin is not only used for ‘unbreakable’ dentures but also to construct of skeletally designed heat cure dentures. This is possibly only with high strength polymers. So, research is continuing for higher strength denture base resin. By comparing the flexural strength and impact strength of all heat cure denture base resins (DPI heat cure acrylic resin, Trevalon, Trevalon HI, and Meliodent heat cure acrylic resins) after irradiation, with flexural strength and impact strength of all heat cure denture base resins before irradiation, it was observed that – irradiated heat cure denture base resins had more impact strength and flexural strength than unirradiated heat cure denture base resins. It was also found that on comparing the hardness of all heat cure denture base resins before and after exposure of radiation, radiated heat cure denture base resins were harder than unirradiated heat cure denture base resins.
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ObjectivesThis study aimed to identify virulent and antimicrobial resistant genes in fecal E. coli in Mbouda, Cameroon.MethodsA total of 599 fecal samples were collected from patients with enteric infections who were ≥ 20 years old. E. coli was isolated on the MacConkey agar and virulent genes were detected by multiplex/simplex PCR. Isolates in which ≥ 1 virulent gene was detected were subjected to antibiotic susceptibility testing. The resulting resistant isolates were subjected to PCR, followed by sequencing for resistant genes detection.ResultsThere were 119 enterovirulent E. coli identified, amongst which 47.05% were atypical enteropathogenic E. coli (EPEC), 36.97% enterotoxigenic E. coli, 10.08% Shiga toxin producing E. coli (STEC) and 5.88% were enteroinvasive E. coli (EIEC). The occurrence of the eae gene (47.06%) was higher compared with CVD432 (33.61%), aaic (13.45%), stx2 (10.08%) and stx1 (0.84%). High resistance rates were noted for ampicillin (94.64% EPEC, 91.67% STEC, 59.09% EAEC, and 57.14% EIEC) and sulfamethoxazole-trimethoprim (100% EPEC and 83.33% STEC, 81.82% EAEC and 71.43% EIEC). sul2 (71.43%), tetB (64.71%), tetA (59.94%) and blaTEM (52.10%) were detected. A double mutation (S83L; D87N) was seen in gyrA and a single mutation (S80I) was observed in parC.ConclusionThese findings suggested that measures should be taken to reduce the harm of E. coli to public health.