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1.
Pakistan Journal of Pharmaceutical Sciences. 2008; 21 (4): 455-459
em Inglês | IMEMR | ID: emr-94295

RESUMO

High shear wet granulation is a preferred manufacturing method of tablets. It allowed for rapid production of compressible granulations. The resultant granulation characteristics depend on a combination of formulation properties and processing parameters. Fully pregelatinized starches are currently being used as binders in wet granulated formulations. But due to the gelatinization, much of the disintegration properties are lost. Partially pregelatinized starches [Starch 1500] have a mixture of properties of both native and fully gelatinized starches; made them useful as both a binder and a disintegrant in wet granulated formulations. Starch 1500 performed as an excellent binder producing a granulation that was compressible and produced Lamivudine tablets of improved hardness and friability compared with those prepared with povidone. The formulation of Lamivudine tablets with Starch 1500 exceeded the disintegration and dissolution performance of the povidone formulation that utilized a super disintegrant. High shear wet granulation is also well suited for the use of partially pregelatinized starches


Assuntos
Lamivudina/farmacocinética , Química Farmacêutica/métodos , Biofarmácia
2.
Pakistan Journal of Pharmacology. 2002; 19 (1): 9-12
em Inglês | IMEMR | ID: emr-60489

RESUMO

The cultural both of a Monocilliuni species upon extraction with ethyl acetate afforded an antimicrobial compound, 5-hydroxymethyl furfural [1]. Both the ethylacetate extract and isolated compound [1] showed strong cytotoxicities in brine shrimp lethality' bioassay. The LC [5] values of ethyl acetate extract and compound 1 were determined graphically and found to be 14.16 mirco g/ml and 27.99 mirco g/ml, respectively


Assuntos
Animais , Antifúngicos , Extratos Vegetais/toxicidade , Fungos/ultraestrutura
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