RESUMO
Interleukin-17 (IL-17) is a proinflammatory factor produced by T helper 17 cells and can induce a variety of chemokines which participate in the body's immunoregulation and inflammatory response.IL-17 can activate various liver cells to produce inflammatory mediators and secrete proinflammatory factors and thus regulate liver inflammation.IL-17 is upregulated in many liver diseases,such as virus hepatitis,fatty liver disease,autoimmune liver diseases,and parasite infection in the liver,and it can promote the development and progression of liver cirrhosis and liver cancer and is associated with liver failure and rejection reaction in liver transplantation.This article reviews the research advances in the role of IL-17 in liver diseases.
RESUMO
Interleukin-17 (IL-17) is a proinflammatory factor produced by T helper 17 cells and can induce a variety of chemokines which participate in the body's immunoregulation and inflammatory response.IL-17 can activate various liver cells to produce inflammatory mediators and secrete proinflammatory factors and thus regulate liver inflammation.IL-17 is upregulated in many liver diseases,such as virus hepatitis,fatty liver disease,autoimmune liver diseases,and parasite infection in the liver,and it can promote the development and progression of liver cirrhosis and liver cancer and is associated with liver failure and rejection reaction in liver transplantation.This article reviews the research advances in the role of IL-17 in liver diseases.