Effect of entecavir combined with Fuzheng Huayu capsules on inflammatory factors and fibrosis markers in patients with compensated chronic hepatitis B-related cirrhosis / 临床肝胆病杂志

ObjectiveTo investigate the clinical effect of entecavir (ETV) combined with Fuzheng Huayu capsules in the treatment of patients with compensated chronic hepatitis B-related cirrhosis. MethodsA total of 142 patients with compensated chronic hepatitis B-related cirrhosis who visited the Sixth People′s Hospital Qingdao from January 2013 to December 2015 were randomly divided into treatment group and control group, with 71 patients in each group. Both groups were given conventional treatment such as liver-protecting and symptomatic treatment. The patients in the control group were given ETV 0.5 mg/day, while those in the treatment group received oral administration of Fuzheng Huayu capsules 1.5 g twice a day in addition to the treatment in the control group. Both groups were treated for 12 months. The changes in inflammatory factors and fibrosis markers were observed. The t-test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. ResultsAfter the 12-month treatment, the treatment group and the control group showed no significant difference in the serum HBV DNA clearance rate ［91.5% (65/71) vs 90.1% (64/71), P=0.771］. Compared with the control group, the treatment group showed significant reductions in serum hyaluronic acid, laminin, procollagen type III, collagen type IV, alanine aminotransferase, aspartate aminotransferase, liver stiffness measurement, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and hypersensitive C-reactive protein (hs-CRP) (t=16187，5343，13697，17121，7409，27371，7973，5471，7885，9057，8171，all P＜0.001). ConclusionCompared with ETV alone, ETV combined with Fuzheng Huayu capsules exerts a better anti-fibrotic effect and can inhibit the release of TNF-α, IL-6, IL-8 and hs-CRP in patients with compensated chronic hepatitis B-related cirrhosis.

Clearance of insoluble depleted uranium particles in lungs by citric acid and ambroxol / 军事医学

Objective To investigate the effect of citric acid and ambroxol on clearing insoluble particles of depleted uranium in rat lungs by establishing a tracheal perfusion model.Methods One hundred and fifty male Wistar rats were randomly divided into model exposure group, normal control group(NC group), depleted uranium exposure group(DU), citric acid treatment group( CA) , ambroxol treatment group( AM) and citric acid+ambroxol treatment group( CA+AM) . The rats were sacrificed on 7, 15 and 30 days.Uranium content in the lungs was detected by microwave digestion method, pathological changes in the lungs were observed, and inflammatory factors of lung homogenates were detected.Results Compared to DU control group, the intrapulmonary uranium deposit amount in experimental groups was significantly reduced on 7 and 15 days (P<0.05).HE stained lung tissue showed that the pathological changes in treatment groups were less significant than in DU control group.The level of IL-1α,IL-1β,and IL-2 was significantly lower than in DU control, but the level of MCP-1 and MIP-1 was observably higher.Conclusion Citric acid and ambroxol can evidently improve the clear-ance of lung uranium and reduce damnification of lung tissues.Drug treatment can reduce the level of pulmonary inflamma-tory cytokines alleviate the chronic inflammation in the lungs, and enhance the capacity of macrophage to recruitment.

Short segment fixation in combination of pedicle screw fixation with bone graft of vertebral body via pedicle for thoracolumbar fractures / 中国矫形外科杂志

[Objective]To assess the clinical outcome of pedicle screw fixation plus bone graft of vertebral body via pedicle for thoracolumbar fractures.[Method]Ninety-six patients treated from 2003-2007 were reviewed.Twenty-eight were treated by short segment fixation(group1).Sixty-eight were treated by short-segment pedicle instrumentation combined with trans-pedicular intracorporeal bone grafting and fixation at the level of the fracture(38 artificial bone as group 2,30 autogenous bone as group 3).Preoperative TLISS(thoracolumbar injury severity score) was evaluated.Radiological evaluation was made for measuring Cobb′s angle,the percentage of the anterior and posterior height of injured vertebra and SI after operation and during the follow-up.[Result]All the patients achieved fracture union during the follow-up with a mean period of 16.8 months(range 12-20 months).All of the fractures were reduced satisfactorily.The height of the injured vertebra,Cobb′s angle correctivity were better in group 2 and 3.There was no difference between those of group 2 and 3.[Conclusion]Short segment plus fracture vertebral segmental fixation can restore the height of vetebra.It is an effcient method for thoracolumbar fracture.