Coexistence of Subcutaneous Panniculitis-Like T-Cell Lymphoma and Dermatomyositis in a 12-Year-Old Boy

Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is an extremely rare, indolent skin malignancy that can be difficult to distinguish from autoimmune disease-associated panniculitides. Here, we describe a 12-year-old boy who was diagnosed at age 7 years with dermatomyositis with classical manifestations, including poikiloderma, Gottron’s sign, and symmetric muscle weakness. Recently, the boy presented multiple subcutaneous nodules and fever. Histopathological examination and immunohistochemical staining revealed coexistence of SPTL. To our knowledge, this is the first case of dermatomyositis accompanied with SPTL. This case alert clinical physicians of the possibility of SPTL should be considered when a patient with dermatomyositis has new lesions presenting as nodules and unknown fever.

Role and mechanism of eosinophils in the pathogenesis of atopic dermatitis / 临床儿科杂志

Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease. Multiple studies have demonstrated a significant correlation between the eosinophil (EOS) and AD. Th2 cells secret cytokines and chemokines mediating the activation, differentiation and growth of EOS. EOS is recruited from bone marrow and blood into the dermis, and releases granule proteins, cytokines etc., resulting in the deposition of collagen and fibrosis thickening. This article reviews the recent studies of the main role and mechanism of EOS in the pathogenesis of AD, aiming to a further understanding of this disease and provides insights for the development of new drugs.