Progress in diagnosis and treatment of coronary artery lesions in Kawasaki disease / 中国小儿急救医学

Coronary artery lesions caused by Kawasaki disease has become the most common cause of acquired heart disease in children, and it is also a key factor affecting the prognosis of Kawasaki disease.The Subspecialty Group of Cardiology, the Society of Pediatrics, Chinese Medical Association has issued an update "Recommendations for clinical management of Kawasaki disease with coronary artery lesions (2020 revision)" . Combining the latest clinical guidelines in China and related researches at domestic and abroad in recent years, the current status of diagnosis and treatments of coronary artery lesions caused by Kawasaki disease is summarized as follows.

Several clinical hotspots in the diagnosis and treatment of myocardial injury and myocarditis in children / 中国小儿急救医学

Myocardial injury and myocarditis are the two diagnostic words frequently used by pediatricians,myocardial enzymes and cardiac troponin are also frequently detected in laboratory tests. But up to now,some pediatricians still lack a comprehensive understanding of the clinical significance of cardiac enzymes and their isoenzymes. There are still some misunderstandings about how to interpret the test results correctly. Currently,it is not uncommon for myocardial injury and myocarditis to be over-diagnosed and over-treated. In addition,new biochemical markers of myocardial injury ( cardiac troponin and highly sensitive troponin) are not well understood. This paper discussed the above clinical hot issues and introduced the relat-ed progress. It is expected that correct cognition can guide the diagnosis and treatment of myocardial injury and myocarditis in children in the future.

Some clinical problems of first-aid medicines on severe cardiac arrhythemias in children / 中国小儿急救医学

Severe cardiac arrhythmias is not rare in chilaren.Because they usually induce striking disturbance of the blood dynamics,heart failure,cardiogenic shock,Adams-stokes attack or sudden death can happen in sick child,therefore they belong to pediatric emergency.Though cardioversion-defibrillation and cardiac pacemaker implantation are widely applied to clinical practice recently,antiarrhythmic drugs are still the most common treatment method at present.In this article,dose and usage,harmful reactions,indications and contraindications of common fist-aid medicines would be introduced,and some important problems in clinical use also be discussed.

Common cause of cardiogenic syncope and emergency treatment / 中国小儿急救医学

Cardiogenic syncope is the relatively common type of syncope in children. The state of illness is more serious at the onset,the prognosis of partial patients is very dangerous,even it can cause cardiac sudden death, so clinical doctors pay close attention to cardiogenic syncope. The common pathogeny of cardiogenic syncope in children includes serious arrhythmia, obstruction of the outflow tract of heart, restricted diastole of heart or weak systole of heart. Before the particular cause of disease is determined,some examinations and laboratory tests should be made. In this article, the writer introduces detailed methods of the emergent treatment.

Effect of adriamycin on calcium current in single cardiac myocyte of gunea pig / 中国药理学通报

AIM To analyze the mechanism of the adriamycin induced cardiomyopathy. METHODS The patch clamp technique in the whole cell recording was used to study the effect of adriamycin on L type calcium channel current( I Ca L ) in the isolated cardiomyocyte of the guinea pig. RESULTS The current voltage( I U ) curveshowed the bell shape in the control and in 0 1 mmol?L -1 adriamycin. Their peak potentials were about +10 mV. The amlitude of peak calcium current increased from (-0 93?0 05) nA to (-1 31?0 08) nA( P