Value analysis of ultrasound-guided fine needle and core needle biopsy of cervical lymph nodes in diagnosis / 中国医师杂志

Objective To compare the value of ultrasound-guided fine-needle aspiration (FNA) and core needle biopsy (CNB) in diagnosing benign and malignant cervical lymph nodes.Methods A retrospective analysis was performed on 88 patients who received biopsy for cervical lymph node enlargement from January 2015 to May 2017.FNA (n =39) or CNB (n =49) were performed respectively to compare the sensitivity,specificity and accuracy of the two methods in diagnosing benign and malignant cervical lymph node enlargement.Results 84.6％ (33/39) of FNA cases were successfully collected,and 98％ (48/49) of FNA cases were successfully collected for definite pathological diagnosis (P =0.000).The sensitivity,specificity and accuracy of FNA and CNB in diagnosing malignant cervical lymph nodes were 90.9％ and 97.2％,94.1％ and 100％,92.3％ and 98％,respectively.Compared with FNA,there were statistically significant differences in sensitivity,specificity and accuracy in differentiating benign and malignant lymphatic lesions in cervical enlargement (P ＜0.01).The sensitivity and specificity of FNA and CNB in diagnosing cervical lymph node metastatic carcinoma were 100％ and 100％,95.2％ and 100％.Compared with FNA,there was no statistically significant difference in the sensitivity to the diagnosis of cervical lymph node metastatic carcinoma (P =0.102).Conclusions CNB is superior to FNA in sensitivity,specificity and accuracy in diagnosing cervical lymphadenopathy.However,when metastatic cancer was diagnosed,FNA was not significantly different from CNB in sensitivity (P =0.102),and FNA was recommended as the first choice.

Application of drug sensitivity from three-dimensional tissue in individualized precision medical treatment for tumor / 实用肿瘤学杂志

At present,most chemotherapy schemes for malignant tumors use the standard chemotherapy regimen recommen-ded by the National Comprehensive Cancer Network(NCCN)clinical practice guidelines,because they ignore the inherent heterogenei-ty of the tumor,resulting in low efficiency,high toxic and side effects,and high costs issues. Therefore,the realization of " individual-ized and accurate medical care" for cancer is a general trend. The sensitivity screening of chemotherapy drugs for cancer patients to a-chieve individualized precise drug delivery is one of the main contents of "individualized precision medicine". The three-dimensional histoculture drug response assay( HDRA) is a method for detecting drug sensitivity after in vitro cultivation of active tumor tissue blocks obtained by surgical resection or biopsy. It not only has a short experimental cycle,but it also maintains the tumor tissue struc-ture,heterogeneity and micro-environment,which have high clinical practice consistency,and it is a relatively promising technique for detecting drug susceptibility. Therefore,this article reviews the development history,clinical application and the future development trend of HDRA.

Risk factors for delirium among older hospital patients: a systematic review and meta-analysia / 中国实用护理杂志

Objective To confirm the correlation between general information、physical functioning and delirium among elderly patients in medical units by systematic review and meta-analysis. Methods With strictly designed search strategies, electronic databases as follows: CBM, CNKI, VIP, WanFang, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Embase, MEDLINE, MEDLINEIn-Process & Other Non-Indexed Citations(OVID), PsycInFo, CINAHL (EBSCO), SCI(Web of Science)were searched dated from the database building to October 2015.Two researchers confirmed the included studies according to the inclusion and exclusion criteria, evaluated the methodological quality of studies and extracted data independently. The Revman 5.3 was used for data analysis. Results (1) Age:results reported indichotomous,combined OR=2.57 (95％CI:1.69-3.89), P<0.00001;results reported in continuous,combined MD=2.67 (95％CI:1.57-3.77), P< 0.01.(2) Male:OR=1.34 (95％CI:0.91-1.97),P=0.14;inverse variance, OR=1.11(95％CI:0.95-1.30), P=0.20. (3)Activities of daily living: OR=2.66 (95％CI:1.90-3.70),P< 0.01. (4)Vision impairment: combined OR=2.31 (95％CI:1.24-4.32), P = 0.009.(5) Physical restraints: OR=6.60(95％CI:4.22-10.31), P < 0.01. Conclusions Physical restraintsis correlative with delirium among elderly patients in medical units. Age, vision impairment, activity of daily living may be correlative with delirium among elderly patients. We suggest to pay attention to those factors to implement delirium prevention, treatment and nursing to reduce the incidence and improve clinical outcomes for elderly patients.

Prilimanary investigation of commence time of liver specific phase on Sonazoid contrast-enhanced ultrasound / 中华超声影像学杂志

Objective To investigate commence time of liver specific phase on Sonazoid contrastenhanced ultrasound.Methods Rats were administrated with saline (n =6),SonoVue (n =24) and Sonazoid(n =24),respectively.Liver perfusion was performed at 2 min,5 min,10 min and 20 min in situ.Changes of liver enhancement caused by perfusion were quantitatively analyzed.Results Degree of liver enhancement without administration of contrast agent increased after perfusion.In SonoVue group,liver enhancement decreased after perfusion at 2 min and 5 min and increased at 10 min and 20 min significantly.In Sonazoid group,liver enhancement decreased dramatically at 2 min after perfusion,but no changes were found at 5 min,10 min and 20 min after perfusion.Conclusions Liver specific phase on Sonazoid CEUS can begin as early as 5min after administration of contrast agent.