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PURPOSE Expression of Rb and p53 gene in gastric carcinomas and its relationship to prognosis as well as clinico pathology were investigated.METHODS Expression of Rb and p53 products and p53 gene mutation in gastric carcinomas were analysed by means of immunohistochemistry and in situ hybridazation.RESULTS p53 gene mutation was found in 6/20(30%).Over expression of Rb and p53 products was found in 62/85(72.94%) and 42/85(49.41%).Both the positive grades showed significant inverse correlation with patient survival( P
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Carbohydrate residues marked by five biotinylatedlectins (Con A, DBA, PHA, PNA, WGA) and carcinoembryonic antigen (CEA) in intestinal metaplasia and dysplasia adjacent to early gastric carcinoma (EGC) were studied immunohistochemically using ABC technique. The results were as following.The distribution of carbohydrate residues in intestinal metaplasia and dysplasia was different from normal gastric mucosa. The ratio of positivity for DBA and CEA was significantly higher in mucosa adjacent to gastric carcinoma than that in intestinal metaplasia in chronic gastritis and gastric resection margins. The new classification of intestinal metaplasia based on lectin binding demonstrated that the metaplasia was predominantly metaplasia of colonic (ConA + PNA-) and mixed types (ConA +PNA + ) in Carcinoma free gastric mucosa of either intestinal or diffuse carcionma. Some of the diffuse gastric carcinomas may originate from the intestinal meiaplasia.
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One hundred and ten cases of early gastric carcinoma (EGC) are analysed pathologically.All cases were operated during the years of 1973-1987 in PLA General Hospital.The rate of EGC in operated gastric cancer cases was about 10% in average.However it was 20.6% in 1987.It occurs frequently among the people over the age of 50 and is usually located at the pyloric antrum.The macroscopica-lly,depressed type (68%) is predominat.The elevated type constitutes only 13.5% of all cases.Histolo-gically,nearly all of the elevated lesions are well differentiated carcinomas,while the majority of the depressed lesions are less or poorly differentiated.It is possible that most of the depressed lesions are the result of the erosion of the neoplastic epithelium by gastric juice.Ulcer cancer is very rare.To examine the specimen carefully and comperhensively is very important in verifying an EGC.The follow-up of the initial 12 cases for a period of about 10 years reveals that there has been no death from gastric cancer.Since patient with EGC who has been operated upon,particularly the elderly,may die of other disease,it is suggested that the prognosis in regard to the gastric carcinoma of the dead should be judged according to the autopsy report.