RESUMO
Objective To investigate the clinical efficacy of vinpocetine in the treatment of coronary heart disease (CHD).Methods 70 patients with CHD were selected,and they were randomly divided into observation group(35 cases) and control group (35 cases) according to the digital table.The control group received routine treatment,the observation group received vinpocetine therapy combined with fluoxetine on the basis of routine treatment.The changes of serum high sensitivity C reactive protein(hs-CRP) and interleukin 6(IL-6) were observed before and after treatment in the two groups,and the clinical efficacy of the two groups was compared.Results Before treatment,there were no statistically significant differences in hs-CRP and IL-6 levels between the two groups (all P ＞ 0.05).Mter treatment,the serum hs-CRP and IL-6 levels in the observation group were (4.18 ± 0.67) mg/mL,(4.42 ±0.52) pg/mL,respectively,which in the control group were (4.51 ± 0.54) mg/mL,(5.96 ± 0.73) pg/mL,respectively,there were statistically significant differences between the two groups(t =2.376,3.218,all P ＜ 0.05).The effective rate of the observation group was 94.3％,which was significantly higher than 80.0％ of the control group,there was statistically significant difference between the two groups (x2 =4.841,P ＜ 0.05).Conclusion On the basis of routine treatment,vinpocetine in the treatment of CHD can significantly reduce the serum levels of hs-CRP and IL-6,and improve the clinical efficacy.
RESUMO
Objective To investigate the influencing factors of surgical treatment of patients with laryngeal cancer.It could provide the better way to treat laryngeal cancer.Methods A total of 80 patients with laryngeal cancer from May 2003 to May 2008 in our hospital were studied.All patients were treated by surgery.The effect of surgery would be observed.The influencing factors and the effect of surgery were analyzed by Logistic.Results A total of 80 patients in the 5-year survival rates were 98.75％ (79/80),76.25％ (61/80),and 51.25％ (41/80).Univariate results showed that age,primary site of the tumor,lymph node metastasis,tumor size,tumor node metastasis(TNM) stage,and treatment modality significantly impacted on the prognosis of patients (P ＜0.01).Multivariate Logistic regression analysis showed that the primary site of the tumor,lymph node metastasis,TNM staging and therapy were independent prognostic risk factors with a statistically significant difference(P ＜ 0.05).Conclusions The prognosis of laryngeal cancer is affected by many factors,the primary sites of tumor,TNM staging,lymph node metastasis,and treatment methods were independent prognostic factors.Laryngeal function preservation surgery is an ideal method in the treatment of laryngeal cancer.