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Objective@#To explore the preoperative anxiety and health information literacy of patients undergoing percutaneous coronary intervention (PCI), and to analyze the correlation between them, so as to provide reference for promoting psychological care of patients.@*Methods@#A total of 221 PCI patients treated in our hospital were selected by convenience sampling, and the preoperative anxiety questionnaire and health information literacy questionnaire were used to investigate.@*Results@#The score of health information literacy of PCI patients was (93.38±11.11) points. The score of information morality was the highest (79.1%) and the score of information acquisition and cognition was the lowest (59.3% and 59.9%). The score of anxiety was (27.07±3.96) points before operation, among them, uncertainty score was the highest with (9.73±1.47) points. The scores of all dimensions of health information literacy were negatively correlated with preoperative anxiety scores (r=-0.354~-0.133, P<0.05).@*Conclusions@#The preoperative anxiety level of PCI patients is relatively high, the higher the health information literacy level of patients, the lower the preoperative anxiety. Nurses should pay attention to improve the health information literacy of patients, reduce preoperative anxiety to improve the outcome of patients.
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Objective To explore the preoperative anxiety and health information literacy of patients undergoing percutaneous coronary intervention (PCI), and to analyze the correlation between them, so as to provide reference for promoting psychological care of patients. Methods A total of 221 PCI patients treated in our hospital were selected by convenience sampling, and the preoperative anxiety questionnaire and health information literacy questionnaire were used to investigate. Results The score of health information literacy of PCI patients was (93.38±11.11) points. The score of information morality was the highest (79.1%) and the score of information acquisition and cognition was the lowest (59.3% and 59.9%). The score of anxiety was (27.07±3.96) points before operation, among them, uncertainty score was the highest with (9.73 ± 1.47) points. The scores of all dimensions of health information literacy were negatively correlated with preoperative anxiety scores (r=-0.354~-0.133, P<0.05). Conclusions The preoperative anxiety level of PCI patients is relatively high, the higher the health information literacy level of patients, the lower the preoperative anxiety. Nurses should pay attention to improve the health information literacy of patients, reduce preoperative anxiety to improve the outcome of patients.
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OBJECTIVE:To study the protective effect of fingolimod on renal ischemia reperfusion injury (RIRI) model mice and its mechanism.METHODS:A total of 60 mice were randomly divided into sham operation group,model group,fingolimod group (1 mg/kg) and fingolimod+wortmannin group [fingolimod 1 mg/kg+phosphatidylinositol 3-kinase (PI3K) specific blocker wortmarmin 1.4 mg/kg],with 15 mice in each group.Except for sham operation group,RIRI model was induced in other 3 groups,and those model mice were given relevant medicine via caudal vein at once 24 h before surgery.Serum of mice were collected in each group after 24 h perfusion.Serum levels of Scr and BUN were measured by automatic biochemical analyzer.The pathological changes of renal tissue were observed under light microscope.The protein expression of intercellular cell adhesion molecule-1 (ICAM-1),monocyte chemoattractant protein-1 (MCP-1) and phosphorylated protein kinase B (p-Akt) in renal tissue were measured by Western blot assay.RESULTS:Compared with sham operation group,the serum levels of Scr and BUN in model group were increased significantly (P＜0.01).Pathological changes were found in the kidney,and RIRI led to widespread renal tubular epithelial cell injury,apoptosis and inflammatory cells infiltration.The protein expression of ICAM-1 and MCP-1 in renal tissue were increased significantly (P＜0.01),the protein expression of p-Akt was increased slightly (P＞0.05).Compared with model group,other indexes of fingolimod group were improved significantly (P＜0.01) except that the protein expression of p-Akt in renal tissue was increased significantly (P＜0.01).Compared with fingolimod group,above indexes of fingolimod+wortmannin group were reversed (P＜0.05 or P＜0.01).CONCLUSIONS:Fingolimod can obviously ameliorate renal injury induced by RIRI in mice,the mechanism of which may be associated with the activation of PI3K/Akt signaling pathway.
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Objective To know the mastery degree of percutaneous coronary intervention (PCI) preoperative nursing knowledge in nurses who are working in emergency department and cardiac ward. Methods 158 cases of nurses who came from three different class Ⅲ grade hospitals with qualification for emergency PCI surgery of the Guizhou province were surveyed with self-made questionnaire. The survey was conducted in nurses who were working in different departments, and the educational background, age, title, category, the cognitive situation of the PCI preoperative nursing knowledge and necessity of preoperative preparations were investigated in nurses. Results The whole pass rate was 48.10%; high qualification, high education, higher title of nurses for the nursing knowledge of the emergency PCI were better; the emergency PCI preoperative preparations for the necessity of cognitive about nurses were on the low side. Conclusion The cognition of the nursing knowledge and the necessity of emergency PCI in preoperative preparations as whole are on the low level, so specialized training should be strengthened to enhance the ability of specialized nursing.
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Objective To analyze the content, quality, the type of nursing documents and the actuality of domestic emergent percutaneous coronary intervention (PCI) in patients with acute myocardial infarction(AMI), and to provide basis and reference for the development of more objective and scientific preoperative nursing guidelines. Methods Wanfang DATA, China National Knowledge Infrastructure (CNKI), CqVIPwere retrieved by computer, and supplemented by manual searches.Then the articles which in accordance with inclusion criteria were analyzed by descriptive analysis. Results A total of 114 literatures from 2004 to 2016 were involved, most of them were presented from 2010 to 2014, all of them were published in nearly 70 kinds of journals. There were merely 9 kinds of nursing journals, 26 literatures in all. Literatures came from different levels of hospital, including 47 provincial hospitals, 50 municipal hospitals, 17county hospitals. Only 3 of them had fund support. According to the types of research, there were 61 quasi- experimental studies, 35 retrospective analysis and 18 experience summarization. The most of literatures about perioperative nursing and whole nursing were 39. Nursing experience literatures were 27, nursing cooperation or nursing intervention or nursing study were 15, others were 12. Only preoperative nursing were 4. All of this content were much the same, with minor innovativeness. Conclusions Researches of domestic nursing scholars on intraoperative and postoperative nursing of emergent PCI are more than preoperative nursing, and the attention to preoperative nursing is not high, we should strengthen the importance to preoperative nursing and increase the study of nursing before the operation in order to strive for the precious time when rescuing patients with acute myocardial infarction.
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Objective To investigate the health information literacy (HIL) conditions of patients after percutaneous coronary intervention (PCI) operation and to discuss the influence of HIL on the nursing knowledge acquisition behavior of the patients. Methods A total of 230 postoperative PCI patients who accepted treatment in Cardiology Department of our hospital were selected. General information questionnaire, 2012 National Residents Health Literacy Supervision Investigation Questionnaire-HIL part and nursing knowledge acquisition behavior questionnaire were adopted. Results In this investigation, 230 questionnaires were recovered and 216 of them were effective. HIL level of PCI postoperative patients was 24.1％ (52/216). Differences in HIL levels of patients of different ages, residential areas and educational degrees were of statistical significance (χ2=10.577, 12.657, 37.693, P<0.05). The scores of PCI postoperative exercise method and item analysis of PCI therapy institution and nursing knowledge obtained from medical care personnel, books, Internet and speeches in patients with HIL were 3.40±0.85, 3.35 ± 0.71, 3.37 ± 0.82, 3.75 ± 0.74, 3.54 ± 0.75 and 3.71 ± 0.82. They were significantly higher than the scores of 2.38±0.71, 2.40±0.76, 2.34±0.71, 2.48±0.75, 2.45±0.72 and 2.43±0.78 in the non HIL patients (t=6.657-9.000, P<0.05). The scores of nursing knowledge in coronary heart disease symptoms, PCI postoperative complications and aetiological agent of coronary heart disease,nursing knowledge sources of newspapers, TV and radio, relatives, and nursing knowledge acquisition barriers due to low educational level, incomprehension of terminology and lack of Internet knowledge of the patients with HIL were 2.37± 0.82, 2.63 ± 0.89, 2.42 ± 0.82, 2.37 ± 0.79, 2.50 ± 0.67, 2.48 ± 0.67, 2.46 ± 0.64, 2.46 ± 0.85, 2.54 ± 0.87 and 2.63±0.69. They were significantly lower than the scores of 3.43±0.78, 3.38±0.76, 3.45±0.74, 3.49±0.77, 3.32 ± 0.81, 3.41 ± 0.77 and 3.34 ± 0.83, 3.46 ± 0.70, 3.43 ± 0.74 and 3.41 ± 0.75 in the non HIL patients (t=-5.657-4.690, P<0.05). Conclusions HIL level of PCI postoperative patients is low, and patients in different HIL levels have different nursing knowledge acquisition behaviors.
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Objective To observe the efficacy of Metoclopramide Dihydrochloride Injection in the prevention of intra-and postoperative vomiting after emergency percutaneous coronary intervention (PCI) in patients with ST segment elevation myocardial infarction.Methods A total of 132 patients with ST segment elevation myocardial infarction and required treatment with PCI were selected from January 2014 to April 2016 and randomly divided into observation group and control group.The patients in observation group were treated with Metoclopramide Dihydrochloride Injection before PCI for preventive treatment,while those in control group were not,only if vomiting occurred,then corresponding symptomatic treatment was provided.The number of patients vomiting,frequency,duration and severity of vomiting during operation and within 24 h after operation were observed.Results The number of patients vomiting,the incidence rate of vomiting and vomiting duration during operation and within 24 h after operation in observation group were significantly lower than those in control group and the score of vomiting severity within 24 h after operation in observation group was significantly lower than that in control group,which indicated statistical differences (P ＜ 0.05).Conclusion Metoclopramide Dihydrochloride Injection is effective for significantly reducing the incidence of intra-and postoperative vomiting after emergency percutaneous coronary intervention (PCI) in patients with ST segment elevation myocardial infarction.