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Objective@#To investigate the current status of knowledge and practice pertaining to nosocomial infection control among medical professionals in grassroots healthcare institutions, so as to provide the evidence of improving the level of infection control in grassroots healthcare institutions.@*Methods@#All medical professionals working in grassroots healthcare institutions in Pukou District, Nanjing City, were enrolled. The participants' demographic features and knowledge and practice of nosocomial infection control were collected using self-designed questionnaires and descriptively analyzed.@*Results@#A total of 402 participants were enrolled, included 116 men ( 28.86% ) and 286 women ( 71.14% ). The respondents were predominantly at ages of 41 years and older ( 187 subjects, 46.52% ), with bachelor and above as the predominant educational level ( 200 subjects, 49.75% ) and intermediate title and above as the predominant professional title ( 168 subjects, 41.79%) , and there were 236 participants ( 58.71% ) with the length of service for more than 10 years. The awareness rate of nosocomial infection control knowledge was 56.22% among medical professionals working in grassroots healthcare institutions, with the highest awareness for COVID-19 prevention and control ( 89.55% ) and the lowest awareness for the key aspects in nosocomial infection control ( 39.55% ). The formation rate of implementing nosocomial infection control practices was 84.08%, with a low rate for “Implement satisfactorily the isolation interventions for patients with multidrug resistant bacteria” ( 71.14% ) and “Implement satisfactorily the control measures for nosocomial infections in key departments and key aspects”( 64.68% ).@*Conclusions@#Low levels are seen in the awareness of nosocomial infection control, behaviors of multidrug resistance management and key aspects in nosocomial infection control among medical professionals in grassroots healthcare institutions in Pukou District.
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Objective:To establish an HPLC method for the simultaneous determination of liquiritin and glycyrrhizic acid in Erxieting granule.Methods:A TechMate C18-ST(250 mm×4.6 mm,5 μm) column with a DAD detector was used.The mobile phase consisted of acetonitrile (A) and 0.05% phosphoric acids in water (B) with gradient elution.The flow rate was 1.0 ml·min-1 and the detection wavelength was 237 nm.The sample size was 5 μl and the column temperation was room temperatence.Results:Linear calibration curves were obtained within the range of 10.32-51.62 mg·L-1 for liquiritin and 79.40-397.00 mg·L-1for glycyrrhizic acid.The average spiked recovery of liquiritin and glycyrrhizic acid was 98.10(RSD=1.0%,n=6)and 97.15(RSD=1.8%,n=6),respectively.Conclusion:The method is accurate,reproducible and stable,and can be used for the quality control of Erxieting granule.
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Objective To observe the effects of analgesia and sedation with dexemetomidine for chronic obstructive pulmonary disease(COPD) patients withdrawn from mechanic ventilation .Methods 48 cases of COPD patients withdrawn from mechanic ven-tilation successfully were assigned into 2 groups :Control group was given Midazolam and fentanyl for analgesia and sedation ;dex-emetomidine group was given Dexemetomidine with a dose of 1 .0 μg/kg ,the intravenous injection time was more than 10 min and the intravenous titration rate at 0 .2 - 0 .7 μg(kg ? h) ,targeting Ramsay grade :3 - 4 ,bispectral index (BIS) :65 - 85 ,and faces pain scale (FPS) :0 - 4 scores .non-invasive blood pressure(NIBP) ,heart rate(HR) ,saturation of pulse oxygen (SpO2 ) ,pressure of end-tidal carbondioxide(PETCO2 ) were detected continuously at 0 ,1 ,2 ,4 h after administration .Results Compared with control group ,systolic blood pressure(SBP) of dexemetomidine group at 1 ,2 ,4 h after administration significantly decreased (P 0 .05) .7 cases in control group droped out for SpO 2 < 90% or PETCO2 escalation over 20 mm Hg ,The test failure rate of dexemetomidine group was significantly lower than that of control group (χ2 =6 .02 ,P< 0 .05) .Conclusion Analgesia and sedation with dexemetomidine in intensive care unit (ICU ) for COPD patients with-drawn from mechanic ventilation were safe and beneficial .