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Objective:To investigate the value of 18F-FDG PET/CT myocardial inflammation imaging in evaluating the functional prognosis of left ventricle (LV) in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI). Methods:Thirty-one patients (26 males, 5 females, age: (55.4±10.1) years) with acute ST-elevation myocardial infarction (STEMI) referred for PCI in Beijing Chaoyang Hospital between January 2016 and December 2016 were prospectively included. All patients underwent 18F-FDG PET/CT following 99Tc m-methoxyisobutylisonitrile (MIBI) rest myocardial perfusion imaging (MPI) on the fifth day after PCI. A comprehensive strategy recommended by guideline was followed to suppress myocardial uptake. 18F-FDG uptake in infarcted and remote myocardium were quantitatively analyzed by measuring SUV max, and that in superior vena cava was quantitatively analyzed by measuring SUV mean. Target-to-background ratios (TBRs) in infarcted and remote area were calculated. In addition, the following parameters were obtained: 18F-FDG uptake volume of LV (Vol-FDG), percentage of 18F-FDG uptake size of LV (F/LV%) , percentage of myocardial perfusion defect size of LV (def/LV%). According to the left ventricular ejection fraction (EF) at baseline and 6 months after AMI, the changing rate of EF (ΔEF) was calculated, and data of patients in improvement group (ΔEF≥10%) and no improvement group (ΔEF<10%) were compared. Independent-sample t test or Mann-Whitney U test, and Pearson correlation analysis or Spearman rank correlation analysis were used for data analysis. Results:TBR was significantly higher in infarcted myocardium than that in remote area (2.8±1.0 vs 1.1±0.3; t=11.03, P<0.001). F/LV% was greater than def/LV% (33.7%(25.8%, 43.3%) vs 8.8%(2.3%, 20.7%); z=-4.72, P<0.001). TBR in both infarcted and remote areas showed positive correlations with peripheral blood monocyte counts ( r=0.44, P=0.014; r=0.37, P=0.042). Vol-FDG had positive correlations with the myocardial injury markers (creatine kinase (CK), CK isoenzyme (CK-MB), cardiac troponin I (cTnI); r values: 0.46, 0.41, 0.68, all P<0.05). Of the 31 patients, 26(83.9%) completed the 6-month follow-up. Vol-FDG in no improvement group ( n=11) was significantly greater than that in improvement group ( n=15; (104.5±47.2) vs (70.1±26.3) cm 3;t=2.38, P=0.026). There was a negative correlation between Vol-FDG and ΔEF ( rs=-0.41, P=0.038). Conclusion:18F-FDG PET/CT imaging can evaluate the intensity and size of myocardial inflammation, and estimate the functional prognosis of LV in patients with AMI undergoing PCI.
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Objective The present study aimed to establish a bone mineral density (BMD) reference database in China and to investigate the prevalence of osteoporosis in Chinese adults aged 50 years and older using dual energy X-ray absorptiometry (DXA). Method A total of 75321 examineers over 25 years old who underwent health checkups in 7 health check centers between 2008 and 2018 were included. All centers used a GE Lunar-DXA system to measure BMD of the lumbar spine (L1-L4), femoral neck, and total femur. The same European Spine Phantom (ESP) was used for scanning 10 times at every center, a regression equation was generated, and BMD data were cross-calibrated in each center. Peak BMD and standard deviation (SD) were identified according to 5-year age groups, and T scores were calculated based on the peak BMD and SD. Osteoporosis was defined according to the World Health Organization criteria. The prevalence of osteoporosis was standardized based on 2010 national census data for the Chinese population. Result The mean BMD values decreased with age, were highest in North China, followed by Northeast China, East China, and Southwest China, respectively, and increased with body mass index. Males aged 20-30 years and females aged 35-40 years had peak BMD values. Peak BMD values of the lumbar spine, femoral neck, and total femur were 1.09 g/cm2, 0.97 g/cm2, and 0.97 g/cm2 in males, and 1.11 g/cm2, 0.84 g/cm2, and 0.88 g/cm2 in females, respectively. Among all scanned sites, the prevalence of osteoporosis was highest in the femoral neck in males (4.58％) and in the lumbar spine in females (23.38％). The age-standardized prevalence of osteoporosis at any site was 6.46％ in males and 29.13％ in females aged 50 years and older. Based on the 2010 national census data, 10879115 males and 49286542 females currently have osteoporosis. Conclusion Mean BMD values varied according to geographic region, body mass index, age group, and sex in Chinese adults. The age-standardized prevalence of osteoporosis was 6.46％ in males and 29.13％ in females aged 50 years and older.
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Objective To observe the effects of Xinshuaiheji (XSHJ) on cardiac function, plasma angiotensin Ⅱ (AngⅡ) and histomorphology in rats with heart failure after acute myocardial infarction. Methods A model of heart failure (HF) induced by myocardial infarction (MI) in rats was made, 10 days after MI, rats were treated for 4 weeks with bidist Water, Captopril, high dosage of XSHJ, low dosage of XSHJ. The effects of Xinshuaiheji on cardiac function (stroke volume, SV, cardiac output, CO, cardiac index, CI ) and AngⅡ were observed. We also observed and compared the changes of heart weight/body weight ratio (HW/BW), ratio of ventricular wall thinning in MI. Results After treatment with XSHJ, the cardiac function (SV, CO, CI) of HF rats improved (P
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0.05).There were obvious expression of PKC in ischemic preconditioning group,drug pretreatment+ ischemic preconditioning group and drug pretreatment group,but the rest groups not.Conclusion Shenyuandan was able to reduce the infarct size of myocardial ischemia in rats and had a pharmacological preconditioning-like myocardial protection,its mechanism may be related to PKC-mediated mechanism.