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Objective:To evaluate the efficacy of Jianpi-Yishen Decoction in treating sarcopenia aged patients with syndrome of spleen-kidney deficiency and cold-dampness. Methods:Eighty-two sarcopenia aged patients admitted to Beijing Longfu hospital from January of 2018 to May of 2019 were selected and divided into the control group and the observation group with 41 patients in each group according to the random number table. Patients in the control group were given routine western treatment such as nutritional support. In the observation group, the patients were given Jianpi-Yishen Decoction based on the control group. Both groups were treated for 12 weeks. Before and after the treatment, the upper limb muscle strength, scores of symptoms of syndrome of spleen-kidney deficiency and cold-dampness, the efficacy of traditional Chinese medicine syndrome, and serum level of 1,25-dihydroxyvitamin D3 were compared between the two groups. Results:During the treatment, one patient in the control group was dropped out. The total effective rate was 95.1% (39/41) in the observation group and 72.5% (29/40) in the control group, and the difference between the two groups was statistically significant ( χ2=6.103, P=0.013). After the treatment, the scores of languid limbs, cold limbs, weak waist and knee, clear urine and loose stool in the observation group were obviously lower than those of the control group ( t values were 9.964, 12.510, 14.103, 13.415, 14.599, respectively, all Ps<0.01). The left hand grip strength (52.75±7.91 kg vs. 46.10 ± 7.22 kg, t=3.954) and the right hand grip strength (53.93 ± 8.09 kg vs. 48.55 ± 7.17 kg, t=3.169) were both higher than those of the control group ( P<0.01). Serum level of 1,25-dihydroxyvitamin D3 (23.90 ± 3.34 ng/L vs. 19.44 ± 3.15 ng/L, t=6.184) were higher than those of the control group ( P<0.01). Conclusions:Jianpi-Yishen Decoction in treating sarcopenia aged patients with syndrome of spleen-kidney deficiency and cold-dampness can effectively relieve the symptoms, up-regulate serum level of 1,25-dihydroxyvitamin D3 with clinical efficacy.
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Objective To investigate the frailty-related serum markers in elderly patients with cerebral infarction and to determine their diagnostic value for frailty. Methods A hundred and fourteen inpatients aged 65 years and over were continuously recruited from department of geriatrics. Participants were assigned into a frailty group and a non-frailty group according to the Fried Frailty Criteria. The frailty group was further divided into mild ,moderate ,and severe feeble groups according to the clinical frailty scales.We analyzed the differences in serum indexes ,the prevalence and incidence of chronic complications and geriatric syndrome between the frailty group and non-frailty group. The ROC curves of frailty-related serum indexes were drawn and the optimal cut-off points were determined. Finally ,the area under ROC curves were calculated and compared. Results A total of 114 elderly patients with cerebral infarction were divided into a frailty group (78/114 ,68.4%)and a non-frailty group (36/114 ,31.6%).Seventy-eight patients (68.4%)in the frailty group had senile cerebral infarction. The prevalence of cerebral infarction combined with hypertension (88.5%) ,angina (53.8%) ,myocardial infarction (32.1%) ,heart failure (34.6%) ,chronic renal disease (28.2%) ,and malignant tumor (24.4%)was significantly higher in the frailty group than in the non-frailty group (69.4%,27.8%,8.3%,13.9%,11.1%,and 8.3%,respectively ;χ2＝ 6.158 ,6.747 ,7.478 ,5.241 , 4.088 ,4.062 ;all P＜0.05). The incidences of malnutrition and falling were significantly higher in the frailty group[28.2%(22/78)and 29.5%(23/78)]than in the non-frailty group[0.0%(0/36)and 2.8%(1/36) ,χ2＝12.582 ,10.572 ;all P＜0.05].Comparing the frailty with the non-frailty group ,the lower serum levels were found in HGB [(115.1 ± 19.7 )g/L vs. (135.8 ± 11.7 )g/L ] ,in LDL-C [(2.5 ± 0.9)mmol/L vs.(3.1± 0.7)mmol/L]and in ALB[(35.3 ± 4.3)g/L vs. (37.9 ± 2.3)g/L](t ＝－4.918 ,－2.536 ,－3.036 ;P＜0.05) ,while the higher serum levels were found in hs-CRP[(10.8 ± 14.3)mg/L vs.(3.1±2.9)mg/L],inD-Dimer[(494.2±412.9)μg/L ,vs.(256.4±221.5)μg/L],and in BNP[(458.0 ± 324.4)ng/L vs. (88.3 ± 68.4)ng/L](t ＝ 3.266 ,2.735 ,6.838 ;all P ＜ 0.05) . Furthermore ,the area under ROC curves of HGB , LDL-C and BNP were more than 0.75. Conclusions Serological markers related to frailty in elderly patients with cerebral infarction are HGB ,LDL-C ,ALB ,hs-CRP ,D-Dimer ,and BNP ,among which the diagnostic values of HGB , LDL-C and BNP are higher.
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Objective To observe the influence of sea sickness elixir on changes in cardiar rhythm in subjects susceptible to sea-sickness. Methods In a double-blind control test, 50 volunteers, 10 persons not susceptible to sea-sickness (controll group) and 40 persons susceptible to sea-sickness to travel their first sea voyage were enrolled. They were divided into three groups, control group (n=10), placebo group (n=20) and test group (n=20). Sea sickness elixir or placebo was administered half an hour before the sea voyage. The 4h dynamic electrocardiogram was collected and the changes in heart rhythm was analyzed using time-domain, frequency domain analysis methods. Meanwhile the symptoms of sea sickness were recorded. Results Sea sickness elixir did have the effect of preventing sea-sickness. The effective rate in the test group (85%) was significantly higher than control group (20%) (P