RESUMO
The LIM domains proteins are of significance proteins of human tumors. LMO3, a member of LIM-only subclass of LIM proteins, participates in the occurrence and development in many kinds of tumors, including neuroblastoma, meningioma, lung cancer and hepatocellular carcinoma, etc. LMO3 functions as interacting with neuronal transcription factor, HUA enhancer 2, interacting with upstream gene and inhibits its transcriptional activity or directly interacting with gene signaling. As an incomparable role in processes of tumors, LMO3 contributes to huge opportunities for therapeutic targeting for the future of the field.This article focuses on the molecular mechanism of LMO3 in the process of tumor development and metastasis, and reviews its recent progress.
RESUMO
The LIM domains proteins are of significance proteins of human tumors.LMO3,a member of LIM-only subclass of LIM proteins,participates in the occurrence and development in many kinds of tumors,including neuroblastoma,meningioma,lung cancer and hepatocellular carcinoma,etc.LMO3 functions as interacting with neuronal transcription factor,HUA enhancer 2,interacting with upstream gene and inhibits its transcriptional activity or directly interacting with gene signaling.As an incomparable role in processes of tumors,LMO3 contributes to huge opportunities for therapeutic targeting for the future of the field.This article focuses on the molecular mechanism of LMO3 in the process of tumor development and metastasis,and reviews its recent progress.