RESUMO
Objective To observe the clinical effect of Jiawei Sinisan (JWSNS) on patients with alcohol liver diseases. Methods 80 patients of alcohol liver diseases were divided into two groups, JWSNS and Xiaochaihu (as control) were used respectively to observe the variation of lipoprotein and the expression of hepatic fibrosis markers. Results The symptoms and indicators of patients were improved by JWSNS. The high variation of lipoprotein and the expression of hepatic fibrosis markers were obviously detected on alcohol liver diseases patients who were treated with JWSNS (with an effectivity of 97.5%). However, patients treated with Xiaochaihu had less therapeutic effect. Conclusions JWSNS can obviously regulate the fat metabolism, resist hepatic fibrosis, and improve the symptom of patients suffering from alcohol liver diseases.
RESUMO
Objective To observe the pharmacological effect of Jiaweisinisan (JWSNS) on alcohol liver diseases. Methods Feeding Wistar rats with alcohol induced the alcohol liver diseases model. Then JWSNS was used on the alcohol liver diseases model to observe the histological variation of liver and detect the effect on the liver’s expression of SOD, GSH-PX, CAT and MDA. At the same time, Xiaochaihu granule group was used as control. Results On the alcohol liver diseases model group processed with JWSNS, obvious decrease of pathological injury with expression of MDA in liver was observed, while a markedly increased expression of SOD, GSH-PX and CAT was detected. Conclusions JWSNS can prevent liver cells from peroxided injury by alcohol.