Contrast study between budesonide inhalation with methylperdnisolone intravenous in the treatment of acute exacerbation of chronic obstructive pulmonary disease / 中国基层医药

Objective To compare the effect and safety between budesonide inhalation with methylperdnisolone intravenous in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 80 patients with AECOPD were divided into the control group and observation group randomly,each group 40 cases.Based on regular treatment,the patients in the control group received intravenous treatment of methylprednisolone,while patients in the observation group receive inhaled treatment of budesonide.The near-term and long-term effect,symptom score,and the indicators such as FEV1/FVC,MMEF,PaO2,PaCO2 and AHR were observed and compared beween the two groups before and after treatment.Results Compared with control group,there were no significant differences of short-term and long term treatment effects and symptom score in observation group(all P ＞ 0.05) ;The indicators of pulmonary function and blood gas analysis improved significantly in all patients after treatments(all P ＜ 0.05),but there were no significant differences between two groups(all P ＞0.05) ;The incidence of side effects in observation group was significantly lower than that of control group (P ＜ 0.05).Conclusion Glucocorticoid in the treatment of AECOPD has clear effect,and regardless of the mode of administration,it has good near-term and longterm effect.But in adverse reactions budesonide inhalation is significantly superior to methylprednisolone intravenous therapy.

Cardiac and Pulmonary Response to Peak Exercise in Patients with Chronic Obstructive Pulmonary Disease / 中国运动医学杂志

Objective To study the effects of cardiac and pulmonary response in pailents with chronic obstructive pulmonary disease(COPD) on their exercise capacity.Methods Thirty four patients with COPD(including 8 patients in stage Ⅰ,15 patients in stage Ⅱ,10 patents in stage Ⅲ and 1 patent in stage Ⅳ and 24 healthy controls performed incremental exercise testing.Oxygen uptake(VO_2) and carbon dioxide output(VCO_2)were measured breath-by-breath.Arterial blood samples were drawn both at rest and peak exercise.Results The VO_2 at peak exercise was significantly lower in COPD group than in control group(15.81±3.65ml/min/kg vs 18.96±6.10ml/min/kg,P=0.042).The respiration reserve was lower in COPD patients compared to controls.The rBorg dyspnea score at the peak exercise for COPD patents was 4.24±2.01,significantly higher than that for controls(1.754±1.50).Oxygen pulse and heart rate reserve had not statistically difference between COPD group and control group.Significant increase of PO_2 and PCO_2 were found during exercise,which were 26.374±15.40 vs 10.26±22.65 mmHg and 42.33±3.65 vs 40.29±4.46 mmHg respectively compared to at rest.Conclusion Abnormal pulmonary response to exercise might be the main cause inducing exercise intolerance in patents with COPD.

Cardiac response to exercise in mild-to-moderate chronic obstructive pulmonary disease / 老年心脏病学杂志（英文版）

Objective Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular problem.The symptom of dyspnea on exertion may be associated with pulmonary dysfunction or heart failure, or both. The study objective was to determine whether cardiac dysfunction adds to the mechanism of dyspnea caused mainly by impaired lung function in patients with mild-to-moderate COPD. Methods Patients with COPD and healthy controls performed incremental and constant work rate exercise testing. Venous blood samples were collected in 19 COPD patients and 10 controls before and during constant work exercise for analysis of N-terminal-pro-BNP (NT-pro-BNP). Results Peak oxygen uptake and constant work exercise time (CWET) were significantly lower in COPD group than in control group (15.81±3.65 vs 19.19a±6.16 ml/min kg, P=0.035 and 7.78±6.53 rain vs 14.77±7.33 min, P=0.015, respectively). Anaerobic threshold, oxygen pulse and heart rate reserve were not statistically significant between COPD group and control group. The NT-pro-BNP levels both at rest and during constant work exercise were higher in COPD group compared to control group, but without statistical significance. The correlations between CWET and NT-proBNP at rest or during exercise in patients with COPD were not statistically significant. Conclusions Heart failure does not contribute to exercise intolerance in mild-to-moderate COPD.

Evaluation of SF-36 in measuring health-related quality of life in Chinese patients with COPD / 中国医师进修杂志

Objective To study the value of SF-36 in evaluating the life quality of Chinese patients with chronic obstructive pulmonary disease(COPD). Methods The SF-36,MRC score and spirometry were collected from 50 patients with COPD,the validity was documented by performing correlation analysis and stepwise multiple regression analysis. Pearson correlation coefficients were calculated. Results The MRC score was significantly correlated with seven of the eight components(P