RESUMO
Long non-coding RNA (lncRNA) is a type of non-coding RNAs (ncRNA), and it involved in a wide range of biological processes. In recent years, the role of lncRNA in the development and progression of tumors has been widely concerned by the field of medical with the further researches. Mounting evidence also shows that many lncRNAs have altered expression in various types of human cancer and involved in the progress of tumor by multi ways. Thyroid cancer is a complex disease of uncertain origin, and it is lack of effective diagnosis, treatment and prognosis biomarkers. Therefore, finding the association between lncRNA and thyroid cancer is very important and helpful for clarifying the pathogenesis and finding new effective biomarkers for this disease.
RESUMO
Long non-coding RNA (lncRNA) is a type of non-coding RNAs (ncRNA), and it involved in a wide range of biological processes. In recent years, the role of lncRNA in the development and progression of tumors has been widely concerned by the field of medical with the further researches. Mounting evidence also shows that many lncRNAs have altered expression in various types of human cancer and involved in the progress of tumor by multi ways. Thyroid cancer is a complex disease of uncertain origin, and it is lack of effective diagnosis, treatment and prognosis biomarkers. Therefore, finding the association between lncRNA and thyroid cancer is very important and helpful for clarifying the pathogenesis and finding new effective biomarkers for this disease.
RESUMO
Metabolomics is a study for comprehensive and systematic description of all small metabolites in biological samples. Metabolomics has obvious advantages in the diagnosis of diseases through the changes of internal and external environment of endogenous metabolites. Metabolomics provides the informative clue for diagnosing malignant tumor. In recent years, studies on thyroid cancer metabolomics have found that small molecular metabolites play a guiding role in diagnosis of the disease. In this paper, the application of metabolomics in diagnosis of thyroid carcinoma will be reviewed.