RESUMO
AIM: Inflammatory responses play an important role in the post- percutaneous transluminal coronary angioplasty (PTCA) restenosis and has been demonstrated occuring immediately after PTCA. Interleukin-6(IL-6) and tumor necrosis factor-?(TNF-?) are the main inflammatory cytokines. We try to compare the changes in interleukin-6(IL-6) and TNF-? after PTCA in the patients with and without collateral circulation to probe into the pathogenesis of early inflammatory response. METHODS: The extent of myocardial ischemia induced by balloon inflation was quantified by a scoring system referring to the Leaman coronary score. The IL-6?TNF-? levels of coronary heart disease group and control group before and after PTCA are calculated. RESULTS: The concentrations of IL-6 and TNF-? were (9.592?1.847) ng/L and (26.959?1.967) ng/L, respectively, and were significantly increased [(27.423?1.882) ng/L and (78.542?1.573) ng/L)] 4 hours after PTCA. CONCLUSION: IL-6 and TNF-? are sensitive indicators of the early inflammatory response after PTCA. Ischemia scores reflected the extent of ischemia reperfusion injury during PTCA. Collateral circulation decreased the early inflammatory response after PTCA.
RESUMO
AIM: To explore the effect of the combination of captopril and losartan on the sICAM-1, sVCAM-1, TNF-?, and TGF-? in the patients with coronary heart disease. METHODS: sICAM-1, sVCAM-1 and TGF-? were measured with ELISA, and TNF-? was measured with RIA in the patients with or without the treatment of captopril and losartan. RESULTS: sICAM-1 and TNF-? decreased, and TGF-? increased distinctly in the patients given a combination of captopril and losartan compared with patients without the drugs. sVCAM-1 had the tendency of decrease in combined therapy, but no significant difference showed compared with the control patients. CONCLUSION: The combination of captopril and losartan has the effects on the cell adhesion molecules and cytokins in patients with coronary heart disease.