Correlation between intestinal glucagon-like peptides-1 and major depressive disorder / 中华行为医学与脑科学杂志

Objective:To explore the pathogenesis of major depressive disorder(MDD) by comparing the serum glucose and lipid metabolism indicators, levels of glucagon-like peptide-1(GLP-1) in plasma and feces, and the content of specific intestinal flora ( Lactobacillus, Bifidobacterium) between patients with MDD who were diagnosed for the first time and healthy controls. Methods:Totally 80 MDD patients hospitalized from January 1, 2020 to March 30, 2021 and 80 healthy volunteers with normal physical examination in the same period were selected. Blood and fecal samples of patients with MDD and healthy controls were collected respectively. The indicators of serum glucose and lipid metabolism were detected by automatic biochemical analyzer, the concentrations of GLP-1 in plasma and feces were detected by ELISA, and the relative contents of Lactobacillus and Bifidobacterium in feces were detected by real-time PCR. The differences between two groups of glucose and lipid metabolism indicators, GLP-1 levels and the relative contents of Lactobacillus and Bifidobacterium in feces were analyzed. SPSS 22.0 software was used for statistical analysis. Independent sample t-test and analysis of variance were used for inter group comparison, and Pearson correlation analysis was used for correlation analysis. Results:Compared with the control group, the levels of serum TC, HDL, and LDL in the MDD group decreased ((3.99±0.85)mmol/L , (4.78±0.86)mmol/L; (1.18±0.29)mmol/L, (1.30±0.28)mmol/L; (2.64±0.70)mmol/L, (3.19±0.69)mmol/L; t=5.559, 2.371, 4.695, all P<0.05). The plasma and fecal GLP-1 levels of the MDD group were lower than those of the control group (plasma: (0.81±0.22)pmol/mL, (1.05±0.26)pmol/mL , t=4.509, P<0.01; feces: (2.23±0.46)pmol/mL , (2.47±0.37)pmol/mL, t=2.533, P<0.05). Compared with the control group, the relative contents of Lactobacillus(2.56±1.59, 3.51±2.21) and Bifidobacterium(2.24±1.89 , 3.17±2.08) in the MDD group decreased ( t=2.218, 2.082, both P<0.05). The level of plasma GLP-1 in the MDD group was negatively correlated with FPG, TG, and disease severity ( r=-0.281, -0.221, -0.437, P<0.05). The level of plasma GLP-1 in the control group was negatively correlated with FPG ( r=-0.580, P<0.01). The fecal GLP-1 level of the MDD group was negatively correlated with the severity of the disease ( r=-0.298, P<0.01), and the fecal GLP-1 level of the control group was positively correlated with fecal Lactobacillus and Bifidobacterium ( r=0.685, 0.428, P<0.01). Conclusion:MDD patients have abnormal glucose and lipid metabolism, decreased GLP-1 level and decreased relative content of intestinal Lactobacillus and Bifidobacterium. Changes in intestinal flora affect GLP-1 levels. GLP-1 can affect glucose and lipid metabolism and depressive symptoms in patients with MDD by binding to specific receptors in intestinal tract and central nervous system.

Association analysis of the rs10043986 polymorphism of cardiomyopathy-associated 5 gene with schizophrenia in Uygur Chinese population / 中华行为医学与脑科学杂志

Objective To evaluate the relationship between cardiomyopathy-associated 5 (CMYAS) gene rs10043986 polymorphism and schizophrenia in Uygur Chinese population.Methods The SNP rs10043986 in CMYA5 gene was genotyped in 325 patients with schizophrenia and 183 normal controls using TaqMan technology.The symptoms of schizophrenia were assessed by positive and negative syndrome scale (PANSS).The association of the loci with schizophrenia,age of onset,clinical symptom was analyzed.Results The allelic and genotypic distributions in rs10043986 between patients with schizophrenia (C,T allele:91.5％,8.5％ ; C/C,C/T,T/T genotypes:83.4％,16.3％,0.3％) and normal controls (C,T allele:96.4％,3.6％ ; C/C,C/T,T/T genotypes:92.9％,7.1％,0) had statistically significance after analysis (x2 =9.038,P=0.003 ; x2 =9.417,P=0.009).Via analysis of stratification by gender and age at onset.The results showed that both allele (x2=11.812,P=0.001) and genotype (x2=12.769,P=0.001) frequency in rs10043986 with patients were significantly different in females,but neither in males (all P＞0.05).Allelic or genotypic distributions between adult cases and controls had statistically significance (x2=8.219,P=0.004; x2=8.379,P=0.015),but there were not significant differences between adolescent cases and controls (all P＞ 0.05).Furthermore,we also notice that the PANSS scores of patients between Genotype C/C and C/T had no statistically significance (allP＞0.05).Conclusion The results reveal that T allele at CMYA5 rs10043986 may be confer risk for susceptibility of female and adult schizophrenia in Uygur Chinese population,and that rs 10043986 polymorphism may not significantly associate with symptoms severity of schizophrenia.

Association of GRM7 gene rs3749380 polymorphism with schizophrenia in Uygur Chinese population / 中华行为医学与脑科学杂志

Objective To investigate the association between GRM7 gene polymorphism and schizophrenia in the Uygur Chinese population.Methods rs3749380 at the GRM7 gene was selected for genotyping in a Uygur Chinese patients-control sample(case=360,control=384) by Taqman assays.The symptoms of schizophrenia were assessed by positive and negative syndrome scale(PANSS).SHEsis on line and SPSS 17.0 soft were used for calculating the data.Results For rs3749380 at GRM7 gene,the C allele frequency was 60.1％,and T allele frequency was 39.9％ in the patients.In the control,the C allele frequency was 58.6％,and T allele frequency was 41.4％.In the patients,the C/C genotype frequency was 38.6％,T/C genotype frequency was 43.1％,and T/T genotype frequency was 18.3％.In the controls,the C/C genotype frequency was 35.9％,T/C genotype frequency was 45.4％,and T/T genotype frequency was 18.7％.rs3749380 was not found to have genotypic or allelic association with schizophrenia(P＞0.05).And genotypic or allelic association with schizophrenia were not found between adolescent and adult cases,adolescent cases and controls or adult cases and controls(P＞0.05).The results showed rs3749380 genotypic or allelic was not association with schizophrenia in the different gender of the population (P＞ 0.05).The genotypes were not significantly correlated with symptoms of schizophrenia(P＞0.05).Conclusion There is no association of GRM7 gene rs3749380 polymorphism with the incidence of schizophrenia in Uygur Chinese.

A study on inducements, clinical features and interventions in a case of mass hysteria / 中国神经精神疾病杂志

Objective To explore the clinical features, inducements and interventions in a case of mass hysteria. Methods A mass hysteria strook after a fight gang in a factory. Fifty-four cases were diagnosed as mass hysteria. The general information and clinical symptoms of all patients with mass hysteria were collected. All patients were assessed us-ing Hamilton anxiety scale (HAMA) before treatment, and at the end of one, two and four weeks of the treatment, respec-tively. Results The patients were thirty-eight females (70.4%) and sixteen males (29.6%), with average age (20.26±2.04) years old. Fifty patients showed anxious about self-safety mostly. The most common symptoms were convulsions or con-vulsive seizure in forty-seven cases (87.0%), outburst of emotion in thirty-two cases (59.3%), and episodic syncope in twenty-nine cases (53.7%). Thirty-four cases (62.96%) were disscoiative disorders mixed with conversion disorders. The scores of HAMA at the end of one, two and four weeks of the treatment were lower than that before treatment (all P<0.05). Conclusions The inducements of such an episode of mass hysteria are witness of fighting and the overwhelming anxiety about self-security. Disscoiative disorders mixed with conversion disorders is the major clinical feature. In order to control the episode of mass hysteria, the priority task is to relieve people’s anxiety.

Meta-analysis of the C270T polymorphism of brain-derived neurotrophic factor gene in schizophrenia / 中国神经精神疾病杂志

Objective To evaluate the relationship between the C270T polymorphism brain-derived neurotrophic factor and susceptibility of schizophrenia using meta-analysis. Methods A retrieval was performed on the case control study on the C270T polymorphism of the patients with schizophrenia. The meta-analysis was applied for investigating and summarizing the relationship between C270T polymorphism and schizophrenia. Subgroups were divided according to races. Results A total of 16 studies with 3874 patients and 4309 controls were included. The frequencies of C/T allele and genotype CC/(CT+TT) were associated with schizophrenia (all P<0.01) with OR 1.65 [95%CI (1.26, 2.16)] and 1.71 [95%CI (1.27, 2.30)], respectively. The association of C/T allele and genotype CC/(CT+TT) with schizophrenia was signif-icant in Asian subgroup (P<0.01), with OR 1.89 [95%CI (1.30, 2.75)] and 1.97 [95%CI (1.29, 3.03)], but not in Cauca-sian subgroup (all P=0.05). Conclusion The C270T polymorphism of brain-derived neurotrophic factor gene might con-tribute to the genetic susceptibility of schizophrenia in Asian population.

The association between the Uygur patients with schizophrenia and CMYA5 polymorphism / 中国神经精神疾病杂志

Objective To investigate the association between Cardiomyopathy associated 5 (CMYA5) polymor?phisms and schizophrenia in the Uygur Chinese population. Methods Taq-man assay was used to detect CMYA5 gene rs3828611 in 684 schizophrenia patients and 678 healthy controls from Chinese population. The positive and negative symptoms scale (PANSS) was used to evaluate patients’symptoms. Results Neither the genotype nor the allele frequen?cies of rs3828611 was significantly different between the patients and the controls (P>0.05). The differences were not sig?nificant in either each gender subgroup or in each age (teenager and adult) subgroup (P>0.05). The total score and the sub scores of PANSS were not significantly different among patients with different genotype groups (P>0.05). Conclu?sions There is no association between CMYA5 rs3828611and schizophrenia in the Uygur Chinese population.

Control study of Stroop test of male juvenile delinquents with aggressive behaviors / 中华行为医学与脑科学杂志

ObjectiveTo explore the characteristic and difference of the executive function of the premeditated group and attack group of male juvenile delinquents by the Stroop test.Methods 123 male juvenile delinquents and 128 normal controls were examined by a general information questionnaire,the Stroop test of the Chinese version and impulsive premeditated aggression scale (IPAS).SPSS17.0 statistical software used to analysis the survey results.Results ( 1 ) By Stroop test the premeditated group and impulsive group of juvenile delinquents was found that correct number of test 3( 109.97 ± 1.87),errors number of test 4(4.45 ±4.84),amend number of test 1 and test 4 ( 1.18 ± 1.50 ; 1.50 ± 1.59 ),and completion time of test 4 ( 143.74 ± 28.36) had statistically significant (P ＜ 0.05 ),the others had no significant difference between the two groups.(2) The premeditated group of juvenile delinquents and normal adolescents in Stroop test comparison was statistically significant in completion time of test 1,test 2 (56.49 ± 14.90 ;88.31 ± 20.02)(P ＜ 0.05 ).The impulse group of the juvenile delinquents and normal adolescents was statistically significant in the correct number of test 2 to test 4( 107.20 ± 3.39 ; 109.97± 1.87 ; 102.47 ± 5.62 ),errors number of test 2 ( 1.86 ± 2.27 ),amends number of test 3 ( 1.50 ± 1.59 ),and completion time of test 1 to test 4 (59.96 ± 11.08 ;92.03 ± 20.87 ;62.77 ± 12.31 ; 143.74 ± 28.36) (P ＜ 0.05 ).The others of two groups were no significant difference.ConclusionIt is found that juvenile delinquents exist defects of executive function,and perform functional defects in the attack group of juvenile delinquents is more obviously.

The correlate and regression analysis of cognitive emotion regulation, live events and depression and suicide ideation in different nationalities / 中华行为医学与脑科学杂志

Objective To explore the difference of risk factors to depression between different nationalities, the relationship of stressing life events, cognitive emotion regulation, and depression and suicide ideation were studied by correlate and regression analysis. Methods 126 patients with depression diagnosed by CCMD-III,55 minority nationality and 71 Han nationality patients,completed life events questionnaires,cognitive emotion regulation questionaire(CERQ) and HAMD. All the parameters be analyzed by SPSS 17.0, and correlation analysis and stepwise regression analysis be employed to analyze the relationship between the parameters. Results Negative cognitive emotion, stressing life events and suicide ideation related positively to depression, while positive cognitive emotion related to depression negatively(r self-blame=0.599,r acceptance=0.527,r rumination=0.484,r catastrophizing=0.618,r LES=0.649,r suicide ideation=0.482,P<0.01;r positive refocusing=-0.476,r planning=-0.0254,r positive reapprasial=-0.363,r putting into perspective=-0.492,p<0.01);stressing life events and negative cognitive emotion and depression related positively to suicide i-deation(r LES=0.482.r self-blame=0.438,r acceptance=0.338,r rumination=0.378,r catastrophizing=0.457,r depression=0.724,p<0.01) , and positive cognitive emotion related negatively to it(r positive refocusing=-0.319,r putting into perspective=-0.326,p<0.01). The outcome of correlate analysis was similar in different nationalities. Stressing life events and catastrophizing and other-blame contributed more to depression than other factors in minority nationality group, and only the former two factors contributed to depression in Han nationality group. In both two groups, depression contributed more to suicide ideation than others. Conclusions Stressing rife events and negative cognitive emotion regulation have a significant effect on the development of depression, and the severity of depression is a critical factor to suicide ideation. There is no significant difference about above outcome between different nationalities.