Investigation on the antibacterial and anti Helicobacter pylori of the tablets Bimix (Colloidal bismuth subcitrate)

Bimix - a produce of CBS have been prepared and tested for inhibitory activity against E. coli, P. aeruginosa, Staphylococcus aureus and Streptococcus faecalis. The efficacy of Bimix also was compared with Gastrostat and Trymo. They had only bactericidal activity in Streptococcus - faecalis. The range of the minimum inhibitory concentration (MIC) for CBS (Bimix) against some H. pylori was 2-32 g/ml

Contribution to the manufacture of an antiacid complex for the treatment of gastric and duodenal diseases from aluminum and magnesium compounds:

Magaldrat, a chemical combination of aluminum and magnesium hydroxides was synthesized from aluminum compounds and magnesium sulfate. The factors, which influence the result, have been investigated. The quality of magaldrate has also been analyzed following the standards of USP XXIII. The product showed low acute and chronic toxicity in vivo.

Designing and optimizing the formulation of tablet of malumix by the artificial intellect system (CAD/CHEM 4.6)

Malumix, an antiacid uncoated tablet, contains Magaldrate as the biological active agent. Its optimal formula was established by using the artificial intelligent software CAD/CHEM 4.6, based on the experimental data of nine designed formulae. The experimental properties of the above dosage form were almost the same in comparison with its predicted ones.

Investigation on security of colloidal bismuth subcitrate compound - Bimix capsules

The acute toxicity of Bimix (CBS) has been tested on mice at the dose of 1.25g/kg once time daily. This dose was equivalent to dose of 73 times the daily therapeutic dose on body weight. No toxic effects were seen. Acute toxicity appeared to be virtually nil. The semi-acute has also tested on mice at the dose 0.125g/kg once daily for 45 days. No accumulated toxicity was observed. No lesion or damage were apparent in the liver and kidneys. The results of experiment showed that CBS could be used for a long time with a little change on haematology and biochemical indices

Investigation on some pharmacological effects of the product magaldrate (malumix) in the treatment of gastric duodenal ulcer

Magaldrate (malumix) is a chemical combination of magnesium and aluminum hydroxides used an antacid. It has a rapid action, high acid consuming capacity. Studies in vitro showed that magaldrate (malumix) possessed some antipepsin activity. At pH = 1.5 proteolysis was inhibited 55% by malumix. Pretreatment with Malumix suspension 30 minutes before ethanol reduced the severity and extent of gastric mucosal lesions at dose-dependent manner. Magaldrate (malumix) had not acute toxicity in vivo test.