Histologic comparison of Bio-Oss and Neo-Oss in bone regeneration of experimental defects on rabbit calvarium

Several biomaterials have been presented for regeneration of intraosseous defects and Bio-Oss is one of the most accepted materials in this field. Neo-Oss may be the first and only regenerative material made in Iran which few studies have been published about it. The aim of this study was the histologic evaluation of Neo-Oss in comparison with Bio-Oss in experimental rabbit calvarial defects. This was an interventional in vivo study. After elevating muccoperiosteal flap 18 standard defects [3X6mm] in frontal and parietal bone were made by round bur on the calvarium of 6 New Zealand rabbits. Defects were randomly assigned to one of the following treatments: 1-No graft [control], 2-Bio-Oss graft 3-Neo-Oss graft. After 4 weeks the animals were killed and histologic sections prepared. The studied variables consisted of inflammation, type of regenerated bone, thickness of bony trabeculation and foreign body reaction. Data were analyzed by Friedman test with p<0.05 as the limit of significance. The results showed that Bio-Oss was effective for bone regeneration. Inflammation [P= 0.026] and foreign body reaction [P= 0.002] in Neo-Oss was significantly more than Bio-Oss group. Thickness of terabecula in Neo-Oss group [66.7% thin] was significantly different from Bio-Oss [100% thick] and control group [50% thin 50% thick] [P= 0.006]. In Neo-Oss group, granulation tissue containing giant cells was observed and the rate of resorption during 4 weeks was high. Based on the results of this study, the healing capacity of Neo-Oss in comparison with Bio-Oss is not acceptable

Controlled tissue expansion in reconstruction of post burn deformities of head and neck

Reconstruction of post burn scars and contractures in the region of head and neck is a difficult task. Introduction of controlled tissue expansion has provided a versatile and reliable technique in management of these cases by providing skin of excellent quality and minimal donor site deformity. A review of forty-five [45] procedures carried out for reconstruction with controlled tissue expansion, between January 1994 and December 2003 is presented. Expanders of various shapes and sizes were used to achieve a fill volume ranging from 140 c.c to 470 c.c over a period of 9 to 12 weeks. Expander was reused in eight [8] expansions and three [3] patients with large defects underwent two or more expansions of the same area to achieve desired results. In 32 cases the procedure was completed without any complications whereas in 10 cases minor or major complications hampered or delayed eventual reconstruction. Only in 4 cases [8.8%] the reconstruction was compromised as a result of early complications. Controlled tissue expansion provides a safe and predictable technique for reconstruction in the region of Head and neck with acceptable rate of complications and provides excellent results

Delay in presentation of acute ischemic stroke in Lahore general hospital, Lahore

To find out the time interval from onset of the symptoms to admission in the hospital of patients suffering from acute ischemic stroke, in order to assess the feasibility of thrombolytic therapy in Lahore General Hospital. Hospital-based, prospective and observational study Lahore General Hospital Lahore. Six months from January - June 2004. Seventy two patients with acute ischemic stroke diagnosed on basis of clinical findings and CT scan. Patients o f a cute ischemic stroke including cerebral infarct, T IA, venous infarct and lacunar infarct were diagnosed on basis of clinical history, examination and CT scan and enrolled in the study. Data was collected on a Performa. Time taken by patients to reach hospital after onset of symptoms, distance of patients' residences from hospital, education level of patients and time required to do a CT scan after arrival of patient in hospital were studied. 54.2% were male and mean age of patients was 60 years. 58 patients had cerebral infarction, TIA's and venous infarction were 8 and 6 respectively. Delay in presentation was divided in three groups. Within three hours [hrs] 15 [21%] patients arrived. 54 and 18 patients arrived in 3-- 24 hrs group and >24 firs group. Mean distance was roughly 44 km. Mean distance for 0-3hrs, 3-24hrs and >24hrs group was 14, 35, and 85 Km respectively. Average time required to do CT scan was nine hours after arrival of patient in emergency department. Sixty-five percent of patients coming were illiterate. Majority of the patients with ischemic stroke present late to. emergency department. Many factors including distance from hospital, illiteracy, non-availability of ambulance services responsible for it. Evaluation-of patients and provision of urgent CT scan is required. in hospitals

Frequency of oesophageal varices among patients undergoing GI endoscopy

At least two thirds of cirrhotic patients develop Oesophageal Varices [OV] during their lifetime. Severe Upper Gastro Intestinal [UGI] bleeding as a complication of portal hypertension develops in about 30%-40% of cirrhotics. Despite significant improvements in the early diagnosis and treatment of oesophagogastric variceal haemorrhage, the mortality rate of first variceal haemorrhage remains high [20%-35%].Aim: To find out frequency of OV in two different areas of Karachi.Method: We prepared a register of 255 patients who underwent upper GI endoscopy at Murshid Hospital and Health Care Centre between 1999 and 2003 and compared it with 254 patients scoped at Hamdard University Hospital Karachi during the same period. At Murshid Hospital oesophageal varices were present in 58 cases 22.75%, age specific occurrence was 10.3% [20-30 years], 25.8% [>30-40 years], 63.7% [>40 years] while at Hamdard University Hospital the frequency of oesophageal varices was 18 cases 7.1%, age specific occurrence at this centre showed that all cases of oesophageal varices were above the age of 45 years. A record linkage population based study of oesophageal varices allows outcomes to be identified and workout the cost. Those at risk in the population should be informed about the future implication to their health and costs. The health service should investigate the increasing incidence and prevalence of oesophageal varices at local as well as national level

Nasal reconstruction with pedicle flaps: a review of 77 cases

A perfect nasal reconstruction still eludes the plastic surgeon. We present a study of 77 cases in which regional and distant pedicle flaps were used for reconstruction of acquired nasal defects. Patients were followed up for 6-94 months; [mean 40.5 months]. Results of various flaps are compared along-with a review of literature