Comparison of plasma leptin levels in patients with normal, low and high risk myocardial perfusion scan

Leptin, secreted from adipose tissue may have some correlation with coronary artery disease according to some reports in literature. The mean concentration of plasma leptin in patients with normal and abnormal myocardial perfusion imaging [MPI] and relation of leptin levels, independently to abnormality in MPI after correction for body mass index [BMI] was evaluated. As a cross-sectional study on 270 patients [July-December 2004], data was collected by questionnaire, history and physical examination. After a 12-hours overnight fast, blood samples were obtained. Myocardial perfusion scan was performed and quantitative assessment according to 17 segments analysis was carried out. For 114[42.2%] males and 156[57.8%] females, mean age was 55.8 +/- 0.7. Frequency of normal, low and high-risk scans were 101 [37.4%], 67 [24.8%], and 102[37.8%], respectively. Close relationship between BMI and leptin levels was observed [r = 0.42]. One-way ANOVA for BMI, leptin, triglyceride, total cholesterol, LDL-C, HDL-C and fasting blood sugar didn't show differences between three groups[p>0.05]. Adjusted odds ratio of leptin for BMI in presence of abnormal MPI was 1.05 [0.95, CI: 0.82-1.4]. Serum leptin level shows no correlation with coronary artery disease risk category or factors [excluding BMI]

[ survey on the distribution of coronary risk factors based on myocardial perfusion scan and dipyridamol test in patients who referred for myocardial perfusion imaging [MPI] to the Nuclear Medicine Department of Shahrood Imam Hossien hospital]

Early diagnosis and treatment of cardiovascular diseases has an important role in reduction of the mortality and morbidity of cardiac events, in view of increasing rate of these disease states. This cross-sectional study was performed to evaluate the distribution of coronary risk factors in 222 patients. HTN and smoking were more common in women and men, respectively, while no such difference was noted for other coronary risk factors. The average and total number of risk factors were greater in the group with positive dipyridamole test and positive MPI, in comparison with the group with negative dipyridamole test and negative MPI, respectively. Older age was consistent with more positive MPIs, but not with positive dipyridamole stress tests. DM and HTN were more common in positive dipyridamole test group but this was not true for other risk factors. A normal MPI was noted in 43.7% of patients. These findings indicated that coronary risk factors play an important role in appearance of ischemia in dipyridamol and MPI test