RESUMO
A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form [C[1]-C[7]] compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by [1]HNMR, IR and Mass spectral data. The compounds were purified by column chromatography. All synthesized derivatives were determined by the carrageenan-induced rat-paw-oedema model for anti-inflammatory activity. The entire compound gives good response for the anti-inflammatory activity: [3-Chloro-N-[5-[3-Chloro-phenyl]-[1,3,4] oxadiazole-2yl] benzamide [C[4]], and [4-Nitro-N-[5-[4-Nitro-phenyl]-[1,3,4] oxadiazole-2yl] benzamide [C[7]]. For this activity, indometacin was used as a standard drug and compared to new synthesized drugs. Some new synthesized drugs have shown better activities for the anti-inflammation