Assessment of normal IgE level in 0-14 year old healthy children in Tehran

In order to determine the normal values of total IgE in children, 3270 sera were taken from 0-14 year old males and females in different parts of Tehran, the capital of Iran. The technique which was used to measure total IgE was ELISA method using monoclonal anti-IgE antibody. The results of this research indicated that the lower value for IgE was detected in children at birth [X=3.53 IU/mL], while the highest value was in 10 year old children [X=74.63 IU/mL]. Therefore, it has been concluded that with increasing age, the IgE level will also increase [r=0.919]. Regardless of the age value, the IgE content in both males and females are the same. But concerning age and sex, the IgE level in four year old girls was higher [X=44.92] than similarly aged boys [X=28.2] [P<0.01], while in eight year old boys, a higher value of IgE [X=66.42] was recorded in comparison to the same aged girls [X=49.59] [P<0.05]

Production and characterization of humoral immune response against mustard gas

One of the promising aspects of the immunological research on chemical war gas is to investigate the immunogenicity of some hazardous compounds such as mustard gas. Mustard gas is categorized as a "hapten" based on its physical and chemical properties. Haptenic chemicals which do not possess immunogenicity could be immunogenic experimentally when conjugated with a suitable protein carrier. To do so, mustard gas was coupled to a protein carrier and injected to an animal model [rabbit]. After hyperimmunization, specific antibodies were obtained through special purification procedures and used in different immunological tests. It was observed that there are two different groups of antibody populations, one against the haptenic group and the other towards the protein carrier