Cocci gram positive infection: regain registry

The Gram positive coccus infections were always preoccupying. In Tunisia, the epidemiological, clinics, therapeutic data concerning these infections remain insufficient. The main objective of this national epidemiological investigation achieved in 13 hospital units in Tunisia is to identify the criteria of choice of antibiotherapy and the profile of patients hospitalized for an infection to Gram positive cocci. This study included 450 patients with an average of 45.35 +/- 21.23 years of which 299 [66.4%] of men and 316 [70.2%] hospitalized in care unit. Two hundred fifty eight patients [62.2%] had one or several medical antecedents, and 145 [32.2%] one or several surgical antecedents. The diabetes [18%] and the chronic renal insufficiency [13.2%] were the two most frequent comorbidities. Signs of gravity to the admission were noted at least 14% of the patients and about 20% of the patients had presented a severe sepsis or a septic shock. The staphylococci [65.4%] were the most frequently the Gram positive cocci isolated follow-up by the streptococci [24.7%]. The resistance of the Gram positive cocci to glycopeptides concerned only one stump cf negative coagulase staphylococcus. Staphylococcus aureus is more frequently responsible for infections of skin and the soft cloths, bone and joint infections and severe sepsis. The rate of success clinic is more elevated in the infectious illness services [84.2% vs 55.3% p<0.0001], whereas mortality is more elevated the services of resuscitation [19.3% vs 3% p<0.0001]. The factors of bad prognosis are age>60 years, in the septic shock, the arterial hypotension to the admission, a score of Glasgow<8 to the admission and an infection to Staphylococcus aureus

Rifampicin and colistin in the treatment of infections from multiresistant acinetobacter baumannii

Nosocomial infections by Acinetobacter baumannii are responsible for an increase in mortality and the duration of hospitalization. Imipenem represented during main years the 'Gold standard' in the treatment of infections due to Acinetobacter baumannii, however the emergence of resistances to this molecule in many hospitals constitutes a significant therapeutic challenge. The good sensitivity of this germ invitro to colistine, increased by the association of rifampicine supported the intravenous use of these antibiotics in vivo. We report our experience with rifampicine-colistine association for the treatment of infections due to Acinetobacter baumannii multiresistant in the surgical resuscitation unit of the CHU Sahloul of Sousse

Copper in rheumatoid arthritis: the relationship to disease activity

A prospective study to detect the role of copper [Cu] in rheumatoid arthritis [RA] and its relation to disease activity was conducted in 185 rheumatoid arthritic patients with various states of disease activity. The results clearly demonstrated that plasma CU [but not erythrocyte Cu] had a direct relation to disease activity. It also suggested that plasma Cu might provide an additional and useful laboratory test for the assessment of disease activity in RA