Effect of amitriptyline on histamine and bethanechol-stimulated gastric secretion in male rats

Amitriptyline, a tricyclic anti-depressant, was tested for its antimuscarinic and antihistaminic effects against bethanechol and histamine-stimulated gastric secretion in male rats. Daily intramuscular injection of Amitriptyline [5 mg/kg body weight] for two weeks proved to be effective only in inhibiting bethanechol-stimulated gastric secretion. Amitriptyline produced a significant reduction in both free and total acidity of the gastric juice, with significant increase in mucin content, but no change in its peptic activity. The role of Amitriptyline in blocking Bethanechol-stimulated gastric secretion may suggest that the ulcer healing is caused by its anticholinergic activity

Effect of chlorpromazine and metoclopramide on the secretion of some hormones and central neurohumors in rat

After 3 weeks of daily intraperitoneal [i.p.] administration of cholorpromazine [10 mg/kg] or metoclopramide [0.15 mg/kg] to male rats, the whole brain levels of norepinephrine and dopamine significantly decreased. Serum prolactin, thyroxine and tri-iodothyronine levels significantly increased as compared to control values. Serotonin and ACTH were affected by chlorpromazine only. Brain histamine level did not change in both groups. It was concluded that drugs which after central dopaminergic mechanisms may exert significant influences on the secretion of some adenohypophyseal hormones. Serotonin may partially counteract the effect of dopamine. Brain histamine is unlikely to contribute in an important way to the major action of chlorpromazine and metoclopramide in the secretion of hormones