RESUMO
Objectives: Propofol is one of the mainly used intravenous anaesthetic used around the globe.However, it is commonly associated with intravascular pain at the time of administration. In this study, we wanted to determine the effectiveness of Tramadol in comparison to Lignocaine in reducing Propofol induced pain
Study Design: Randomized clinical trial
Study Setting: It was performed in Main Operation Theatre, AK CMH Rawalakot; over a period of seven Months from 27-09-2013 to 27-04-2014
Subjects and Methods: 100 patients, having ASA I and ASA II who had presented for elective surgery, were included in the study. Patients with psychiatric disorder or hypersensitivity to lignocaine, propofol or tramadol were excluded. They were divided into two groups of 50 each. Group A received 50 mg intravenous Tramadol, followed by 25 % of dose calculated for Propofol [2 mg/kg]. Drugs were injected into most prominent vein of hand, using 20 G cannula, at rate of 1 ml/sec. Group B received 2 ml of 2 % lignocaine, followed by Propofol in same manner. IBM SPSS version 20 was used for statistical analysis. Independent sample T-test was used for find out p value for age. Chi square was used to find out p value for gender and pain. Pain was assessed by anesthetist as per patient's facial response or complaint of pain
Results: Mean age was 31.94 +/- 17.59 and 29.86 +/- 13.58 in group- A and B respectively [P value=0.07]. Group A comprised of 33 female and 17 males, whereas Group B comprised of 30 females and 20 males [P value =0.534]. Pain was present in 7 [14%] patients in group A as compared to 11 [22%] patients in group B [P value=0.298]. Statistically the difference in regards to gender or pain was insignificant
Conclusion: The study concludes that there is no significant difference between pretreatment with tramadol or lignocaine, in relieving pain caused by propofol?