RESUMO
A high-fat diet can cause obesity and type 2 diabetes mellitus. This study aimed to observe the antioxidant compounds ofCordyline terminalis’s leaf extract which have the ability to be in vitro antioxidant and antidiabetic. Phytochemical tests andIC 50 to dpph were carried out in vitro. The study was conducted in vivo using 24 female wistar rats, which were dividedinto 4 groups: control of normal rats, high fat diet in obese rats, extract 100 mg / kg bw and extract 200 mg / kg bw. After30 days of research, blood samples were taken for examination of triglycerides, glucose, and free fatty acids. The resultsshowed that methanol extract contained saponins, steroids, flavonoids, alkaloids and polyphenols. The methanol extract canreduce free radicals with IC50 88.25 ppm. In vivo test results showed that there was a significant differences (p <0.05) in thelevels of TG, glucose and free fatty acids with the treatment of methanol extract (100 mg / kg bw and 200 mg / kg bw)compared to the high fat group. Based on the results of the study, it can be concluded that the methanol extract of andongleaves contained antioxidant compounds that act as antidiabetic in obese wistar rats.