RESUMO
Background: The course of chronic kidney disease [CKD] is complicated by dyslipidemia defined as changed plasma lipid levels and abnormalities of lipoproteins associated with early onset of atherosclerotic events. The altered pattern of lipid and lipoproteins metabolism results in rapid progression to end stage renal disease [ESRD] and atherosclerosis. The aim of this study was to see the pattern of dyslipidemia in CKD patients and to evaluate the effects of various sociodemographic variables on patterns of lipids and lipoproteins
Methods: This was a cross- sectional observational study conducted in Ayub Teaching Hospital, Abbottabad. In group-I, 313 patients of CKD were included in the study and 150 subjects with normal renal functions were taken as control. Serum lipid profile was evaluated for both groups. Effects of sociodemographic variables like age, sex, BMI, diabetes, hypertension and duration of renal failure was assessed. Data were analysed using SPSS-17 and p<0.05 was taken as significant
Results: Out of 313 subjects, 144 [46%] were female and 169 [54%] were male. The mean age of the patients was 48.48+/-14.78 years and it was 46.20+14.90 in controls. Most common type of dyslipidemia was hyperlipidemia of low density lipoprotein cholesterol [LDL-C] present in 90% patients. Hypertriglyceridemia was observed in 72% of patients. Low values for high density lipoprotein cholesterol [HDL-C] was observed in 28% of CKD group. Very low density lipoprotein cholesterol [VLDL-C] was found raised in 72% of CKD group. The most frequent dyslipidemia in combination was high LDL-C and high TG [201, 64%]. Eighty-two [26%] of patients had a combination of high triglycerides [TGs] and low HDL-C
Conclusion: Significant dyslipidemia does develop in vast majority of chronic renal failure [CRT] patients. This is an important risk factor associated with early onset of atherosclerosis
RESUMO
Background: Visfatin is a novel adipocytokine, secreted by the visceral fat of humans and mice. Its level increases in plasma during progression of diabetes and development of obesity. The objective of study was to determine the levels of visfatin in obese and diabetic BALB/c strain of albino mice
Methods: It was a quasi experimental study. Ninety BALB/c strain albino mice were procured from NIH, Islamabad and divided into three groups. Animals in Group I [n=30] were grown obese by feeding high fat/high carbohydrate diet whereas Group II [n=30] were turned insulin dependent diabetic by injecting streptozotocin. Group III [n=30] served as control. Blood samples were collected to measure the blood glucose, lipid and visfatin levels. Visfatin levels were measured by enzyme-linked immunosorbent assay [ELIZA], and p
Results: Visfatin levels were significantly raised in obese and diabetic mice
Conclusion: Diabetes Mellitus and obesity are strongly associated with increased serum visfatin levels in BALB/c strain of albino mice