Immune complex membranoproliferative glomerulonephritis associated with transjugular intrahepatic portosystemic shunts in alcoholic cirrhosis: two case reports

Objective: To report on 2 patients with alcoholic cirrhosis who were treated with transjugular intrahepatic portosystemic shunt [TIPS] placement

Clinical Presentation and Intervention: The 2 patients had a history of alcoholic cirrhosis, and TIPS surgery was performed on them. In both cases, 4 months after TIPS placement, proteinuria was observed along with histological alterations characteristic of immune complex membranoproliferative glomerulonephritis [MPGN]

Conclusion: The TIPS in one patient was successful without Immediate complications, while the other patient was referred for a combined liver-kidney transplant. In both cases, immune complex MPGN might have developed after TIPS placement probably due to a reduced immune complex