rare case of alpha 1-antitrypsin deficiency associated with hypogammaglobulinemia and recurrent pulmonary thrombosis

Alpha 1 -antitrypsin [AAT] belongs to the family of serpins [serine protease inhibitors]. Loop sheet polymerization is the pathology behind serpinopathies which encompasses AAT, anti-thrombin III and neuroserpin deficiency. To the best of our knowledge, we report the first case of alpha 1-antitrypsin deficiency associated with hypogammaglobulinemia and recurrent pulmonary thrombosis without any concomitant use of drugs

Rose-K versus Soper contact lens in keratoconus: a randomized comparative trial

To perform a comparative evaluation of the efficacy and acceptability of Rose-K and Soper contact lenses in Keratoconus. Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi. A randomized comparative clinical trial was performed in keratoconic eyes fitted with Rose-K [Rose-K group] and Soper [Soper group] contact lenses. Patients data were evaluated for best spectacle corrected visual acuity, best contact lens corrected visual acuity [BCLCVA], corneal topography, glare acuity, contrast sensitivity, tear function tests and specular microscopy. Patients were also asked to complete a self-reported comfort questionnaire at each visit. Sixty eyes were randomized to the Rose-K and Soper groups. The two groups were comparable in all the baseline parameters. There was a statistically significant improvement in BCLCVA in both groups at 3 months [P < 0.01, both groups]. The difference between in BCLCVA in both groups was not statistically significant. In both groups, there was a significant improvement in the comfort score at 3 months compared to baseline [P< 0.05, both group]. The Rose-K group had statistically significantly better scores at 1 and 3 months compared with the Soper group [P- 0.006 and P< 0.001 respectively]. Both groups were associated with a significant [P< 0.0l], but comparable improvement in glare acuity at 3 months. There was a significant improvement in contrast sensitivity at 3 months in both groups [P< 0.0l]? the Rose-K group was significantly better than the Soper group at 1 and 3 months [P= 0.001 and 0.002 respectively]. The mean number of trial lenses required for fitting Rose-K lens [2.00 +/- 0.59] was significantly lower than the Soper lens [3.43 +/- 0.82; P< 0.00l]. Both the contact lens designs provide an equal improvement in visual acuity in patients with Keratoconus. However, Rose-K contact lens provides greater comfort, better quality of vision and requires less chair time compared with the Soper lens and hence may possibly have a greater acceptability