Safety and efficacy of Esmolol as add on therapy in acute unstable angina

The present study examined the hemodynamic and anti-ischemic effects of esmolol in 20 patients with unstable angina. Two patients required a termination of infusion at the titration period because of hypotension, but they recovered hemodynamic stability within 30 minutes of termination of the infusion. During esmolol infusion, two patients of those receiving intravenous nitroglycerin required a downward adjustment of nitroglycerin infusion rate to maintain systolic blood pressure >90 mm hg. These results suggested that esmolol safely and effectively lowered both arterial pressure and heart rate in patients with acute ischemia