Frequency of Candida Infection in Post Chemotherapy Acute Leukemia Patient with Febrile Neutropenia

Objective: In this study our main goal is to evaluate thefrequency of candida infection in post chemotherapy febrileneutropenia patient with acute leukemia.Method: This prospective type of observation study carried outat Department of Haematology of Bangabandhu Sheikh MujibMedical University (BSMMU) from September 2016 to August2017. A total 63 patients of acute leukaemia (AML and ALL)were admitted in the Department of Haematology in BSMMU.Patients were selected by purposive sampling. A typedquestionnaire was supplied to all patients and those who gavethe written consent were selected as cases.Results: In the study, it was found that 19 (30.2%) patientsbelonged to age ≤20 years followed by 19 (30.2%) of 21-30years, 13 (20.6%) 31-40 years, 6 (9.5%) 41-50 years and 6(9.5%) >50 years of age. Immunophenotypically AML wasfound in 35 patients which was 55.6% of study population, BALL in 9 (14.3%), T ALL in 5 (7.9%) and APL in 2 (3.2%)patients. Majority of the patients 28 (44.4%) were found inconsolidation phase of chemotherapy followed by 26 (41.3%)in induction phase, 5 (7.9%) in relapse, 3 (4.8%) in re-inductionand 1 (1.6%) in palliative phase. 6 (9.5%) patients were foundpositive for throat swab for Candida in this study and bloodculture were negative for candida. Among the AML patients 4(66.7%) patients were found positive for candida in throat swaband 36 (64.3%) were found negative.Conclusion: In the study, it was found that among candida inthroat swab were more common in AML than ALL. Cause wasunknown but might be due to Reduce duration of neutropeniaby applying G-CSF and empirical local and systemic antifungaltherapy.

Glycemic and Insulinemic Responses to Commonly Consumed Potatoes in Bangladeshi Type 2 Diabetic Subjects.

Glycemic indices (GIs) and insulin responses are useful for measuring biological effects and consequences of carbohydrates when designing healthy diets, particularly for people with or at risk of developing diabetes and others disorders such as metabolic syndrome. In this study, we investigated GIs and insulin (as measured by C-peptide) responses of patients with type 2 diabetes mellitus (T2DM) to Bangladeshi potatoes and sweet potatoes. Using a cross-over design, ten T2DM subjects consumed equivalent carbohydrate amounts (50 g of total carbohydrate) of either the vegetables or white bread (WB) (as reference food). Serum glucose levels were determined after 0, 15, 30, 45, 60, 90, 120, 150 and 180 minutes, and C-peptide levels were determined at 0 and 180 minutes. Glycemic Indices and Glycemic Loads (GLs) were calculated. Both plain and sweet potatoes showed a significantly higher serum glucose response compared to the reference food. The similar glycemic response between plain and sweet potatoes was reflected in their GI values: 162  50 and 191  66, respectively. The GL values were 8 and 11, respectively. The substantially higher glycemic response and GI values of the two potatoes were not the consequence of a suppressed insulin response. Compared to the mean values of the international table, Bangladeshi potatoes and sweet potatoes are very high GI foods. However, based on the dietary practices in our society, potatoes and sweet potatoes may be used as low and medium GL foods, respectively. This work may help create a better food exchange table for diabetic patients.