Effect of Albendazole Therapy in Parenchymal Neurocysticercosis Lesion Resolution, Lesion Load Reduction and Lesion Stage Evolution Observed on Serial Neuroimaging in Patients Presenting with Seizures

Neurocysticercosis (NCC) is the commonest parasitic disease of nervous system in humans and single most common cause of acquired seizures in developing countries. In this study, we intended to evaluate the effect of Albendazole therapy in Parenchymal Neurocysticercosis lesion resolution, lesion load reduction and lesion stage evolution observed on serial neuroimaging in patients presenting with seizures. Albendazole was given for 1 month. Patients were followed up and neuroimaging was carried out after a 6-month interval. Temporal changes in lesion profile including lesion load reduction, lesion resolution, lesion stage evolution and seizure recurrences during the interval period were observed. After Albendazole therapy for 6 months, patients were followed up with serial neuroimaging. Lesion resolution was seen in 29.33%, lesion load reduction in 41.33% and calcified lesions in 52% cases.

Adherence to the anti-epileptic drugs among children with epilepsy- a cross sectional study in a tertiary care hospital

Background: Epilepsy is the commonest chronic and highly stigmatized neurological problem that affects many children. It is defined by two or more unprovoked seizures. The main stay of the epilepsy management is the anti-epileptic drugs and strict adherence to anti-epileptic drugs is the key to successful treatment. The 70% of children will become seizure free with appropriate anti-epileptic drug (AED) treatment. The goal of treatment of epilepsy includes minimizing the risk of recurrent seizures and side effects, and maintaining normal psychosocial and educational/vocational adjustment. Our study will assess the level of adherence to AEDs in children and factor associated with non-adherence.Methods: A cross-sectional prospective descriptive design study, conducted in Government medical college and Rajindra hospital, Patiala, Punjab from December 2021 to May 2021. 60 patients were included in this study who gave written consent and had been taking at least one AEDs for at least 6 months. Only those patients with normal neurological and cognitive development and no other severe comorbidities were included in this study. Patients and their parents were individually administered a structured questionnaire consisting of personal and demographic Information, self-prepared questionnaire to check compliance and validated questionnaire called Morisky medication adherence scale (MMAS-8). Data was analysed by using statistical package for social science software and p<0.05 considered as significant to see the association between factors and non-adherence.Results: The most common reason for non-compliance was problem in remembering that was seen in 41.8% of the patients. 21.8% of the patients had problems in sticking themselves and 18.6% had problems with buying the drugs. 60% patients are male.Conclusions: Poor adherence was seen in 50% of our study participants. In our study, patients were not stick to their therapy, buy the drugs or had problem to remember to take their medication.

Direct Esthetic Rehabilitation of Teeth with Severe Fluorosis Using Uveneer Facial Template: A Case Report.

“Dental fluorosis,” a specific disturbance in tooth formation and an esthetic condition, is defined as a chronic, fluorideinduced condition, in which enamel development is disrupted and the enamel is hypomineralized. Fluorosis can be prevented by having an adequate knowledge of the fluoride sources, knowing how to manage this issue and therefore, avoid overexposure. Controlling the fluoride intake is the best preventive measure for dental fluorosis, however when this is already installed and causing esthetic problems to the patient, many treatment techniques are recommended. This article describes an esthetic rehabilitation of a case of severe fluorosis using a new system for placing direct composite veneer, the Uveneer System (Ultradent) which simulates predictable shape and symmetry of natural teeth. In cases of severe dental fluorosis, the tooth enamel usually becomes porous and tooth whitening methods are not recommended. Therefore, minimally invasive technique of direct composite veneering using facial templates is the treatment of choice as it is easy to use, enhance clinical productivity, saves time, requires minimal preparation and is cost effective.