RESUMO
HDCS was given to 12 healthy volunteers in three different schedules. The levels of neutralising antibodies were determined by ELISA test. The antibodies could be detected on day 7 after vaccination. With 3 doses (D-0, D-15, D-30) satisfactory high level of neutralising antibodies could be detected in 3 out of 4 volunteers till 2 years. With 2 doses (D-0, D-15) similar levels could be observed only till day 270, and with single dose significant levels could be seen till day 30 only after which levels declined and no antibodies could be detected on day 270. Reactogenicity of the vaccine was nil as no major or minor side-effects were observed in any of the volunteer.
Assuntos
Adulto , Anticorpos Antivirais/sangue , Diploide , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Esquemas de Imunização , Masculino , Testes de Neutralização , Raiva/imunologia , Vacina Antirrábica/administração & dosagem , Fatores de TempoRESUMO
Rabies is responsible for a large extent of morbidity and mortality in human beings. However, the long incubation period of the disease allows the effective utilization of post exposure immunization. Till recently neural tissue vaccines were the mainstay of antirabic immunoprophylaxis. These vaccines are, associated with severe neuroparalytic complications. The recent introduction of human diploid cell vaccine and chick embro fibroblast vaccines have heralded a new era in antirabic vaccination because of their high immunogenicity and lack of major side effects.