Sebaceous Cell Carcinoma- Two Rare Case Reports

Bonafide sebaceous carcinoma is extremely rare neoplasm. It may be seen as a component of Muir-Torre syndrome. It should be distinguished from basal cell carcinoma with sebaceous differentiation.

Pigmented Basal Cell Carcinoma of Eyelid: A Case Report

Pigmented basal cell carcinoma is a rare cutaneous variant of BCC with very few cases reported. Exposure to sunlight is the most important environmental risk factor.Pigmented basal cell carcinoma is a very rare variant of basal cell carcinoma that exhibits increased pigmentation.As it is rare, thereby we report here the case of Pigmented basal cell carcinoma on eyelid. Key

Correlation between Peripheral Blood Thrombocytopenia and Bone Marrow Findings – A Study of 100 Cases

Thrombocytopenia (platelet count less than 150,000/µl) is commonly encountered in routine hematological investigations. Here we present a study done to understand the prevalence of various conditions leading to thrombocytopenia, referred for bone marrow examination. It is a retrospective study done on 100 cases of thrombocytopenia referred for bone marrow examination in a tertiary care hospital from January 2016 to October 2016. The commonest cause of thrombocytopenia for which bone marrow was sought came out to be megaloblastic anemia followed by acute leukemia and aplastic anemia. Aim: Calculate the prevalence of various conditions causing thrombocytopenia, in cases referred for bone marrow examination, and Understand the various megakaryocytic alterations in hematological disorders presenting with thrombocytopenia due to different mechanisms. Methods: A retrospective study was done on 100 patients of thrombocytopenia referred for bone-marrow aspiration in a tertiary care hospital catering to both rural and urban population from January 2016 to October 2016. All cases of thrombocytopenia (platelet count less than 1,50,000/µl) diagnosed on hematology analyzer and later confirmed by peripheral blood film examination, referred for bone marrow examination for various reasons were included in this study. Stained bone-marrow aspirate smears were examined. Records regarding the clinical indication for the procedure, peripheral blood smear reports, blood counts and significant findings on bone-marrow aspiration smears were retrieved. The role of bone-marrow aspiration in the diagnosis of hematological and non- hematological disorders was reviewed in the study. Results: The commonest cause of thrombocytopenia for which bone marrow examination was sought was megaloblastic anemia(76%), followed by acute leukemia(7%), aplastic anemia(5%), myelodysplastic syndrome (4%) which was followed by ITP(3%), and one case each of gelatinous marrow transformation, malaria and NHL spillover. Conclusion: Further studies on the evaluation of megakaryocytic alteration and their contribution to thrombocytopenia can provide growing knowledge to the pathogenesis of numerous hematopoietic disorders that may identify broader clinical applications of the newer strategies to regulate platelet count and functioning.

Incidence of Molar Pregnency on Histopathological Examination- A Retrospective Study

Hydatidiform mole is an abnormal gestation characterized by trophoblastic hyperplasia and overgrowth of placental villi. H. mole is classified as complete (CHM) and partial (PHM). The diagnosis is based on histopathology and genetic origin. In our set up, we used only histopathological diagnostic criteria. The incidence of molar pregnancy varies in different parts of the world. Objective of the present study was to determine the frequency, clinical presentation and morphological features of H. mole and compare them with those of other studies. Objectives: The aim of this populationbased retrospective study was to evaluate the trend in the incidence of molar pregnancy. The reported incidence of GTD in India is in consistent therefore we planned to do an analysis of the GTD at our institute which is a referral tertiary center of Punjab. Methods: Records of patients of GTD admitted from Dec 2016 to March 2018 were analyzed and incidence was calculated. The diagnosis of hydatidiform mole was based on the post-operative morphological and/or pathological findings. A total of 150 cases of retained products of conception received in the department of pathology were analysed. Results: Out of total 16 cases of molar pregnancy 5 were diagnosed as complete mole and 11 were diagnosed as partial mole. Out of 5 cases of complete mole, one case was of recurrent molar pregnancy. Conclusion: There is a need to look further about the association of age with molar pregnancies in future studies.

Retrospective Study of Histopathological Findings in Non-Neoplastic Cervical Lesions

The uterine cervix is prone to several non-neoplastic gynecological lesions. These lesions are a source of morbidity and mortality in women. Therefore, there is need to analyze them to provide the pattern of these lesions. AIM: Retrospective study of the findings of non-neoplastic lesions of cervix. Methods: A retrospective study was done in Department of Pathology, Government Medical College, Patiala from January 2016 to January 2018. Results & Conclusion: Out of 220 cases, the most common non neoplastic lesion recorded was chronic cervicitis (45.9%) followed by squamous metaplasia(37.2%) and nabothian cysts(36.3%).