Precocious puberty in a boy with hCG secreting tumour in the pituitary gland

We present a rare case of germinoma initially presenting with features of cranial diabetes insipidus, which responded to treatment with intranasal DDAVP. Thirteen months later the patient re-presented with signs of precocious puberty due to ectopic hCG secretion by the tumour. This is an unusual presentation of a rare tumour in children

Adipsic hypernatremia with a reset osmostat, A clinical study

This case clinical study describes a 10-years old boy with idiopathic adipsic hypernatremia associated with reset [shift to right] osmostat for arginine vasopressin [AVP] secretion, combined with a relative deficiency of AVP. His clinical course was characterised by intermittent exacerbation of chronic hypernatremia due to lack of thirst. The pathophysiology of adipsic hypernatremia and the practical difficulties in the management are discussed