RESUMO
The liquid membrane phenomenon in the actions of digitalis glycosides (digitoxin, digoxin and ouabain) has been studied. Formation of liquid membranes, in series with a supporting membrane, by digitalis alone and by digitalis in association with lecithin and cholesterol has been demonstrated. The results obtained on the transport of relevant permeants, viz. sodium, potassium and calcium ions and dopamine, adrenaline, noradrenaline and serotonin, in the presence of the liquid membrane generated by digitalis in association with lecithin and cholesterol indicate that the liquid membrane barrier to transport may have a relevance with the biological actions of digitalis.
Assuntos
Colesterol/química , Digitoxina/química , Digoxina/química , Membranas/metabolismo , Micelas , Ouabaína/química , Permeabilidade , Fosfatidilcolinas/química , Potássio/metabolismo , Sódio/metabolismo , Propriedades de SuperfícieRESUMO
Modifications in the transport of relevant permeants to their respective sites of action due to the liquid membranes formed by prostaglandins in association with lecithin and cholesterol have been discussed in the light of biological actions of prostaglandins. It has been shown that the phenomenon of liquid membrane formation is likely to make a significant contribution to the biological actions.
Assuntos
Alprostadil/fisiologia , Dinoprosta/fisiologia , Fluidez de Membrana/fisiologia , Membranas Artificiais , PermeabilidadeRESUMO
The liquid membrane phenomenon in benzodiazepines has been studied. Transport of glycine, GA-BA, noradrenaline, dopamine and serotonin in the presence of the liquid membranes generated by the benzodiazepines in association with lecithin and cholesterol has been studied. The data indicate that modification in permeabilities in the presence of the liquid membranes is likely to make a significant contribution to several biological actions of the benzodiazepines.