Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 10 de 10
Filtrar
Adicionar filtros








Intervalo de ano
2.
Indian J Physiol Pharmacol ; 1976 Jan-Mar; 20(1): 17-21
Artigo em Inglês | IMSEAR | ID: sea-106436

RESUMO

Oral administration of 2.5 mg of prednisolone/100 gm B.W. to starved forestomachectomized albino rats for three days induces 5-7 acute gastric ulcers with a severity of 3+ in 86% of the rats in the corpus comparable to human gastric ulcers with an ulcer index of 17.1. When 15 mg of Phenobarbital/100 gm B.W. was concomitantly administered with prednisolone either orally or subcutaneously prevents the formation of steroid induced ulcers probably due to their insensitization of gastric epithelium to corticoid ulcerogenic induction. This preliminary observation may have a therapeutic value as this sedative has a common usage. It is is suggested that forestomachectomized rats are best suited for ulcerogenic experiments.


Assuntos
Doença Aguda , Animais , Gastrectomia , Masculino , Fenobarbital/uso terapêutico , Prednisolona/antagonistas & inibidores , Ratos , Úlcera Gástrica/induzido quimicamente
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA