Effect of trigonella, allium sativum and their mixture on some physiological parameters in hyperthyroidimic rats

Background: alterations in the level of hormones including thyroid hormones lead to physiological/ clinical abnormalities

Aim of work: this study aimed to illustrate the protective effect of Trigonella, Allium sativum or their mixture against hyperthyroidism induced by L-thyroxin in male albino rats

Materials and methods: thirty albino rats were divided randomly into five groups. Group A: healthy rats, Group B: normal rats were subcutaneously injected with 500 micro g/kg body weight L-thyroxin once daily for two weeks to induce hyperthyroidism, Group C: hyperthyroid rats received oral dose of 250 micro g/kg body weight/day Trigonella extract. Group D: hyperthyroid rats received oral dose of 250 micro g/kg body weight/day Allium sativum extract. Group E: hyperthyroid rats received mixture of Trigonella and Allium sativum extract. At the end of the experiment. Blood samples were collected for biochemical analysis

Results: Hyperthyroid rats had significant increase [P<0.05] in serum levels of triodothyronine [T[3]], thyroxin [T[4]], TG, VLDL,AST,ALP,BUN and uric acid as well as a significant decrease in TSH, LDL, HDL, LDL/HDL and TC, total protein and percentage of body weight change compared to the normal control group. Oral administration of these extracts ameliorated most of the tested parameters

Conclusion: This study concluded that Allium sativum,Trigonella or their mixture have a protective effect against hyperthyroidism

Assessment of laryngeal affection in patients with rheumatoid arthritis

Rheumatoid arthritis [RA] is a chronic inflammatory disease affecting the synovial membrane, which causes joint damage and bone destruction. The crico arytenoid joint is a true diarthroidial synovial joint that can be affected by RA. In this study, disease activity, clinical assessment of the larynx, fiberoptic nasolaryngoscopy and Multi-Slides Computed Tomography [MSCT] were done to 20 RA patients in order to define the laryngeal involvement in rheumatoid arthritis patients. 14 of the 20 patients [70%] had laryngeal symptoms related to CA arthritis. Laryngeal endoscopy showed abnormalities in 9 of 20 patients [45%]. 5 of the 20 patients [25%], had abnormal radiologic findings related to CA arthritis. Laryngeal symptoms attributable to laryngeal involvement could be predictive of abnormal endoscopic and radiologic findings. Laryngeal involvement in RA could be attributed to the current disease activity and are more frequent with longer disease duration