RESUMO
Purpose: Sildenafil citrate is widely used drug for the treatment of Erectile Dysfunction (ED) and Ginseng is a natural aphrodisiac reported to benefit this condition. The objective of the present study was to develop orodispersible tablets (ODTs) containing combination of Sildenafil citrate and Ginseng extract to improve the bioavailability, reduce the dosing frequency and thereby maintaining the therapeutic efficacy of the drug. Methods: The ODTs were prepared using superdisintegrants such as Croscarmellose sodium (CCS), povidone, and sodium starch glycolate (SSG) at varying concentrations (2%, 4% and 6%) by direct compression. The bitter taste of Sildenafil citrate was masked by Doshion resin. The optimized formulation based on least disintegration time (DT) was chosen to reformulate using sublimating agents such as camphor, menthol or thymol at varying concentrations (1%, 2%, 3%) to further reduce the DT. The compatibility of drug with excipients was investigated and the prepared formulations were evaluated for pre and post-compression parameters. Results: The post-compression parameters such as weight variation, hardness, friability, DT and in-vitro drug release was found within specified limit. The formulation with camphor (2%) had DT of 12 sec and drug release >90% within 5 min hence was considered as optimized formulation. The accelerated stability study and kinetics modelling was performed for optimized formulation. Conclusion: The formulated Sildenafil citrate and Ginseng ODT’s were found to be promising formulation with quicker DT and drug release which will eventually have higher bioavailability and better efficacy along with averting the issues of swallowing and improving patient compliance.
RESUMO
Objective: Herbal shampoo is gaining immense popularity among all consumer groups due to rising awareness about the side effects of chemical formulations. It was also observed that not many marketed shampoos incorporated excellent hair nurturing properties of curry leaves. The aim of the study was to formulate and evaluate herbal shampoo using Murraya koenigii, Phyllanthus emblica, Acacia concinna Linn., Trigonella foenum-graecum, Sapindus mukorossi and perform a comparative analysis with marketed formulation. Method: Three formulations were prepared using extracts of Murraya koenigii, Phyllanthus emblica, Acacia concinna, Trigonella foenum-graecum and Sapindus mukorossi in definite proportions. Decyl Glucoside and Sodium Lauryl Sulphate were added as surfactant in adequate amount. The formulated shampoo was evaluated for organoleptic properties (colour and odour), pH, surface tension, viscosity, dirt dispersion, cleansing action, foaming ability and stability studies. Results: The formulated shampoos were brown in colour with good acceptable fragrance. All the formulations showed good cleansing and detergency power with stable foam. F1 showed comparatively better foaming ability. All the formulations had neutral pH and low surface tension (21-25 dyn/cm). The solid content was found to be in the range of 23-27 % and viscosity 4885 cP- 4903 cP. The results of the prepared formulations were compared with a marketed formulation and were found that F1 formulation was on par with marketed formulation. Conclusion: The prepared shampoo had good characteristics. It was further inferred that it is possible to develop safer and equally effective shampoo using ingredients of plant origin.