RESUMO
Isoniazid (INH) is an integral component of treatment of tuberculosis. An acute overdose is potentially fatal and is characterized by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. The diagnosis of INH overdose should be considered in any patient who presents to emergency medical services (EMS) with the triad. We report a patient presenting with multiple generalised tonic clonic (GTC) convulsions with severe metabolic acidosis as a manifestation of INH toxicity. ©
RESUMO
Isoniazid (INH) is an integral component of treatment of tuberculosis. An acute overdose is potentially fatal and is characterized by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. The diagnosis of INH overdose should be considered in any patient who presents to emergency medical services (EMS) with the triad. We report a patient presenting with multiple generalised tonic clonic (GTC) convulsions with severe metabolic acidosis as a manifestation of INH toxicity. ©
Assuntos
Acidose/induzido quimicamente , Acidose/diagnóstico , Acidose/tratamento farmacológico , Adulto , Antituberculosos/efeitos adversos , Bicarbonatos/administração & dosagem , Bicarbonatos/uso terapêutico , Soluções Tampão , Diuréticos Osmóticos/uso terapêutico , Feminino , Humanos , Isoniazida/efeitos adversos , Manitol/administração & dosagem , Manitol/uso terapêutico , Piridoxina/administração & dosagem , Piridoxina/uso terapêutico , Estado Epiléptico/induzido quimicamente , Estado Epiléptico/diagnóstico , Estado Epiléptico/tratamento farmacológico , Complexo Vitamínico B/administração & dosagem , Complexo Vitamínico B/uso terapêuticoRESUMO
Two cases are reported in which depression was associated with the use of calcium channel blocker, nifedipine. In one instance, a patient became unresponsive to treatment with nortriptyline when nifedipine was introduced. In both cases, the depression resolved following discontinuation of nifedipine.
Assuntos
Bloqueadores dos Canais de Cálcio/efeitos adversos , Depressão/induzido quimicamente , Feminino , Humanos , Hipertensão/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Nifedipino/efeitos adversosRESUMO
We report a rare case of Alprazolam poisoning presented with coma and respiratory depression in a young girl with positive family history of suicidal attempts by her father, mother and sister. The Alprazolam was available in large amount in form of "Physicians Samples" as her elder sister was a medical representative. The patient was successfully managed.
Assuntos
Adulto , Alprazolam/intoxicação , Ansiolíticos/intoxicação , Coma/induzido quimicamente , Feminino , Humanos , Insuficiência Respiratória/induzido quimicamente , Tentativa de SuicídioAssuntos
Adolescente , Adulto , Animais , Mordeduras e Picadas/complicações , Criança , Feminino , Humanos , Índia/epidemiologia , Masculino , Pessoa de Meia-Idade , Raiva/prevenção & controle , LobosRESUMO
A sporadic case of Ehlers-Danlos syndrome associated with atlantoaxial dislocation, mitral valve prolapse and dental abnormalities is presented. This case could not be assigned to any of the nine defined types of the syndrome.