RESUMO
Objectives: To study the drug utilization pattern in Medical Intensive Care Unit (MICU) in a tertiary care teaching hospital in rural area of Maharashtra. Materials and Methods: It was a retrospective and observational study, conducted during the period of March, 2013 to August 2013. Data was obtained through the prescription record of 123 patients admitted in the Medical ICU in the hospital from Medical Record Department (MRD) of the hospital. The study was conducted after obtaining permission from the Institutional Ethics Committee (IEC) of the college. Data was analyzed for- Most common causes for admission to MICU, male and female admission ratio, average number of drugs prescribed per prescription, Outcome of the patients, percentage usage of various antimicrobial groups. Results: Most common cause for admission in MICU was found to be Myocardial Infarction (MI) followed by angina. In all diseases number of male patients was found to be more than female patients. Average no of drugs per patients was found to be 7.82, Improvement was seen in 87.23% patients and mortality was seen in 2.23% patients. While condition remained same in 10.54% patients at the time of discharge. Cephalosporins were the most commonly prescribed antimicrobial group (65.33%) followed by aminoglycosides.
RESUMO
The present work was undertaken to study and compare the gastric ulcerogenic action of analgesic antipyretic agents in guinea pigs. Their interaction with sodium salicylate was also studied. It was observed that aspirin, both microfined and ordinary, phenylbutazone, indomethacin and sodium salicylate were highly ulcerogenic in guinea pigs, while paracetamol and ibuprofen did not exhibit this action. It was also observed that sodium salicylate did not modify the ulcerogenic action of aspirin (both ordinary and microfined), phenylbutazone, ibuprofen and paracetamol but antagonized significantly the ulcerogenic action of indomethacin.