Comparative study between lines of treatment on menopausal osteoporotic women

Menopausal women are at high risk for osteoporosis than adult women. This study was carried on 60 postmenopausal women with age ranged 45-65 years old, and the last menses was at least one year before. Bone densimetry was performed for every case to confirm the diagnosis. These cases were classified into four groups: group I [control]: 20 postmenopausal women without osteoporosis and not on treatment. Group II: 20 osteoporotic postmenopausal women and not on treatment. Group III 10 osteoporotic postmenopausal women and on hormone replacement therapy [HRT]. Group IV: 10 osteoporotic postmenopausal women and on vitamin D, calcium and exercise therapy. Lines of treatment include hormonal replacement therapy, calcium supplements, vitamin D, fluoride therapy, calcitonin and diphosphonates. In this study, the most two common lines of treatment [HRT and calcium, vitamin D and exercise] were used and results compared. The urinary deoxypyridinoline links as a marker for bone degradation showed improvement by both lines of therapy. It was significantly decreased when compared to osteoporotic women on no treatment. It is advisable to use calcium supplements, vitamin D and exercise to avoid the hazards of HRT which may include venous thrombosis, fibromyomas and other complications. The success of calcium, vitamin D and exercise to improve osteoporosis make this line of treatment advisable to be used in women as well as in men who suffer from osteoporosis to avoid any hazards of anabolic steroids

Some immunological abnormalities in bronchiectatic children

This study was conducted on - twenty patients with bronchiectasis and 20 apparently healthy children. Their ages ranged from 6-12 years. This article examined the immunoglobulins level [IgG, IgM. IgA] alpha-1 antitrypsin and auto-antibodies on 20 bronchiectatic children as well as 20 control Children The studied group showed a significant [P<0.05] higher mean lgG and IgA as compared to the control group. As regard IgM and alpha-1- antitrypsin there was increased mean levels of IgM and alpha-1- antitrypsin among bronchiectatic children but this was statistically insignificant. Auto-antibodies showed highly significant value [P<0.01] when compared to control. There was a positive significant correlation [P<0.05] between alpha-1 - antitrypsin and IgG while this correlation was insignificant [P>0.05] between alpha-1 -antitlypsin and gM as well as alpha-1 antitrypsin and IgA bronchiectatic children

Role of endogenous antioxidants after experimental uninephrectomy and contralateral clamping of renal artery in albino rats

This study was done to investigate lipid peroxidation by measuring MDA in plasma in experimental uninephrectomy and contra-lateral renal clamping in albino rats. The role of endogenous, antioxidants plasma sodium dismutase [SOD], catalase, vitamin E and vitamin C to antagonise lipid peroxidation was measured. Also, total lipids, blood urea and creatinine was measured to detect lipid peroxidation process and chronicity of tested rats. MDA significantly elevated in tested rats and endogenous antioxidants was lowered as compared with control and sham operated rats except plasma SOD level increased. Also, total lipids, blood urea and creatinine significantly elevated in tested rats after two months. So, it was suggested that whenever patients with renal impairment with hyperlipidaemia develops renal insufficiency, it is better to add antioxidant drugs like vitamin E and vitamin C which may be protective to vessel wall damage in such cases