Synthesis, spectroscopic characterization and biological applications of Cu(II) and Ni(II) complexes with 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone.

Cu(II) and Ni(II) complexes of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone (L) are synthesized and characterized by using spectroscopic techniques like elemental analysis, FT-IR, mass spectrometry, electronic and EPR spectra. The complexes are found to have characteristic electronic spectra and the geometry of the complexes are identified as octahedron. Both the complexes are found to exhibit similar anti-microbial activity against the gram –ve and gram +ve bacteria. Anti-cancer activity against the cancer cell lines (MDA-MB 231 cell lines) among the compounds studied for % of viability, the inhibition concentration 50 values were shown by Cu(II)-L complex at 80 mg/ml and by Ni(II)-L complex at 100 mg/ml.

Synthesis, spectroscopic characterization and antimicrobial activity studies of 2-Butyl-4-chloro-5-formylimidazole thiosemicarbazone and its manganese (II) complex.

A novel chelating tridentate organic ligand, 2-Butyl-4-chloro-5-formylimidazole thiosemicarbazone(L) is synthesized and characterized by using spectroscopic techniques like elemental analysis, FT-IR, 1H and 13C NMR, UV-vis and Mass spectrometry. The free ligand is then used for the synthesis of Mn(II) complex thoroughly characterized by FT-IR, EPR and electronic spectral analysis. The complex is found to have characteristic d5 electronic spectrum and the geometry of the complex is identified as octahedron based on the g value obtained from the EPR spectrum. Both the ligand and Mn(II)L2 compounds are found to exhibit similar antimicrobial activity against the gram –ve and gram +ve bacteria.