Synthesis and in vitro Anti Microbial Evaluation Including Anti-Malarial Activity of Pyrazole Based Novel Cinnoline Derivatives.

A Series of 4-methyl-3-[5-(substituted phenyl)-4, 5-dihydro-1H-Pyrazol-3-yl] Cinnoline-6-Sulfonamide were synthesized from 4-methyl-3-acetylcinnoline-6-Sulfonamido chalcones and hydrazines. The structure of the synthesized compounds were characterized by UV, IR, NMR & Mass spectral data, and evaluated for their in vitro anti-malarial and anti-bacterial activity to get new congeners as analogs of Pyrazole based Cinnoline compounds as a potent anti-Malarial and anti-microbial agents. All analogues exhibited in vitro anti-malarial activity against Plasmodium falciparum and all the analogues showed good anti-bacterial activity against various pathogenic microbes.

Synthesis and in-vitro Anti Tumor Activity of Some Novel 2, 3-Disubstituted Quinazolin 4(3H)-one Derivatives.

A series of 4-[2-(4-chlorobenzyl)-4-oxoquinazolin-3(4H)-yl)benzoyl] derivatives were synthesized. The synthesized compounds were characterized by IR, NMR and Mass spectral data and were screened for their anti cancer activity.The in vitro anticancer studies were performed on 4 selected compounds using MTT assay against HeLa cell line (NCCS).The synthesized 2, 3-disubstituted-3H-Quinazolin-4-one derivatives exhibited significant Anti oxidant and anti tumor activities.