RESUMO
Background: Vitamin D binding protein DBF is a multifunctional transport protein. The aim of the present study is to measure the level of DBF and serum 25-hydroxyvitamin D 250HD in order to assess its role as a nutritional marker in CF, In the context of the recently described immunomodulatory functions of vitamin Dt the relationship between vitamin DBF and immunoglobulm G IgG levels was assessed
Methods: This is a cross sectional case controlled observational study recruiting 50 patients diagnosed as CF [cystic fibrosis].They were referred to Allergy and Pulmonology Unit, Aboreesh Children's Hospital, Cairo University. Their age ranged years: DBF and 250HD were measured using Elisa technique and IgG was measured using nephelometer method
Results: CF group had significant lower serum concentrations of DBF p<0.012 and 250HD p< 0.001 while IgG levels were within normal values p<0.216 compared to the control group. Significant positive correlations were observed between IgG and age r-0.528, p<0.01 weight r=0.480, p<0.001 and height r=0.509, p<0.001. Significant positive relations were observed between failure to thrive and DBF p=0.023 and 250HD p=0.003. A significant positive relation between DBF and pancreatic insufficiency p=:0.039.No significant correlations were observed between DBF and 250HD r=-0.224, p=0.118, between DBF and IgG r=0.195; p =0.176, between DBF and sweat chloride test r=0.201, p=0.162, between 250HD and IgG r=0.195, p=0.I76.No significant relations were observed between pancreatic insufficiency, and 250HD p=0.944 and IgG p=0.332, between failure to thrive and IgG p=0.898
Conclusions: DBF and 250HD levels were decreased in CF patients; and IgG levels were within normal values and positively correlated with age, weight and height. Significant relations of DBF with failure to thrive and pancreatic insufficiency emphasizing its role as a marker for the nutritional status in CF patients