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1.
IJMS-Iranian Journal of Medical Sciences. 2013; 38 (2): 198-201
em Inglês | IMEMR | ID: emr-181052

RESUMO

Deficiency of vitamin B12 and/or folic acid as a cause of pyrexia, though known, is rarely reported in literature. We aimed to report a case in a 51 year old woman, who presented with fever and pancytopenia and was diagnosed to have megaloblastic anemia secondary to vitamin B12 and folate deficiency. The pyrexia subsided following the intramuscular injection of vitamin B12 and oral folic acid administration. All the other infective, inflammatory/autoimmune, endocrine causes of pyrexia were excluded by appropriate investigations. Therefore, we suggest that all physicians be aware of megaloblastic anemia as a treatable cause of pyrexia in order to avoid unnecessary costly investigations and antibiotic usage

2.
Singapore medical journal ; : e185-9, 2013.
Artigo em Inglês | WPRIM | ID: wpr-337881

RESUMO

Isolated deletion of the long arm of chromosome 20 [del(20q12)] is a rare abnormality in patients with de novo myelodysplastic syndrome. It is characterised by refractory thrombocytopenia, minimal haematological dysplasia and a lower risk for progression to acute myeloid leukaemia. Its distinction from chronic autoimmune thrombocytopenia, although clinically and morphologically difficult, is critical. We report a case of refractory cytopenia and unilineage dysplasia in an elderly woman with isolated del(20q12), identified via fluorescence in situ hybridisation analysis of her bone marrow. In order to avoid a misdiagnosis, we suggest that cytogenetic analysis be performed on all patients suspected to have myelodysplastic syndrome with predominant thrombocytopenic presentation.


Assuntos
Idoso , Feminino , Humanos , Biópsia por Agulha , Células da Medula Óssea , Patologia , Deleção Cromossômica , Cromossomos Humanos Par 20 , Citometria de Fluxo , Hibridização in Situ Fluorescente , Síndromes Mielodisplásicas , Diagnóstico , Genética
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